https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/384 2026-07-04T13:14:44Z https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/185750 Title: Risk of short- and long-term pulmonary complications should be determined before surgery for tuberculosis-destroyed lung Authors: Park, Dong Won; Kim, Bo-Guen; Jeong, Yong Ho; Jang, Hyo Jun; Yang, Bumhee; Shin, Sumin; Lee, Hyun Abstract: [No abstract available] 2023-03-01T00:00:00Z https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/140812 Title: Video-assisted thoracic surgery sleeve resection and bronchoplasty using 3D imaging system: its safety and efficacy Authors: Seong, Yong Won; Jeon, Jae Hyun; Jang, Hyo-Jun; Cho, Sukki; Jheon, Sanghoon; Kim, Kwhanmien Abstract: Background Video-assisted thoracic surgery sleeve resection with bronchial anastomosis or bronchoplasty is a technically demanding procedure. Three-dimensional endoscopic surgery has been reported to be helpful in decreasing operation time and improving spatial perception with less surgical errors, but there have been rare reports about relatively difficult thoracoscopic procedures utilizing 3D thoracoscope. We performed this study to evaluate early clinical outcomes of thoracoscopic sleeve resection and bronchoplasty utilizing 3D thoracoscope. Methods Data from a total of 36 patients who underwent thoracoscopic sleeve lobectomy or bronchoplasty at our institution from December 2015 to October 2017 were retrospectively reviewed. Three-port approach with one utility incision was used with a 10 mm, 30 degrees three-dimensional thoracoscope. Twenty-three patients (81%) were male, and mean age was 65.9 +/- 9.4 years. Fourteen patients (38.9%) underwent sleeve resection with bronchial anastomosis, 22 (61.1%) underwent wedge or simple bronchoplasty, and one patient received concomitant PA procedure. Bronchial anastomosis sites were not covered with viable tissue flaps. Results There was no (0%) suture needle injury from spatial misperception during bronchoplasty or sleeve anastomosis. There was no (0%) operative mortality. The pathologic report revealed squamous cell carcinoma (63.9%), adenocarcinoma (19.4%), carcinoid (6.9%), adenosquamous carcinoma (3.4%), and sarcomatoid carcinoma (2.8%). One (2.8%) late mortality was due to systemic recurrence of sarcomatoid carcinoma. There was no (0.0%) anastomotic failure. The mean number of dissected lymph nodes were 27.4 +/- 13.2, and mean operation time was 216.8 +/- 60.0 min. Median postoperative 24-h drain amount was 315 mL. Median chest tube days and hospital days were 4 and 6, respectively. Two patients (5.6%) had complications greater than Clavien-Dindo grade II-one case of ARDS, and the other case of a delayed bronchopleural fistula. Conclusions Thoracoscopic sleeve resection and bronchoplasty utilizing HD 3D thoracoscope is a safe and effective procedure with excellent early clinical outcomes. Further investigation for long-term outcomes will be needed. 2021-10-01T00:00:00Z https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/145051 Title: Incidence and Mortality Rates of Thoracic Aortic Dissection in Korea – Inferred from the Nationwide Health Insurance Claims Authors: Lee, Jun Ho; Cho, Yongil; Cho, Yang Hyun; Kang, Hyunggoo; Lim, Tae Ho; Jang, Hyo Jun; Ro, Sun Kyun; Kim, Hyuck Abstract: Background: Aortic dissection (AD) is one of the most catastrophic diseases and is associated with high morbidity and mortality. The aim of this study is to investigate the hospital incidence and mortality rates of thoracic AD in Korea using a nationwide database. Methods: We conducted a nationwide population-based study using the health claims data of the National Health Insurance Service in Korea. From 2005 to 2016, adult patients newly diagnosed with AD were included. All patients were divided into the following four subgroups by treatment: type A surgical repair (TASK), type B surgical repair (TBSR), thoracic endovascular aortic repair (TEVAR), and medical management (MM). The incidence rate, mortality rate, and risk factors of in-hospital mortality were evaluated. Results: In total, 18,565 patients were newly diagnosed with AD (TASK, n = 4,319 [23.3%]; TBSR, n = 186 [1.0%]; TEVAR, n = 697 [3.8%]; MM, n = 13,363 [72.0%]). The overall AD incidence rate was 3.76 per 100,000 person-years and exhibited a gradual increase during the study period (3.29 to 4.82, P< 0.001). The overall in-hospital mortality rate was 10.84% and remained consistent (P= 0.57). However, the in-hospital mortality rate decreased in the TASK subgroup (18.23 to 11.27%, P= 0.046). An older age, the female sex, hypertension, and chronic kidney disease were independent risk factors for in-hospital mortality. Conclusion: The incidence of thoracic AD has gradually increased in Korea. The in-hospital mortality in the TASR subgroup decreased over the decade, although the overall mortality of AD patients did not change. 2020-10-01T00:00:00Z https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/10787 Title: Role of MicroRNA-34a in Anti-Apoptotic Effects of Granulocyte-Colony Stimulating Factor in Diabetic Cardiomyopathy Authors: Park, In-Hwa; Song, Yi-Sun; Joo, Hyun-Woo; Shen, Guang-Yin; Seong, Jin-Hee; Shin, Na-Kyoung; Cho, Young Jong; Lee, Yonggu; Shin, Jeong Hun; Lim, Young-Hyo; Kim, Hyuck; Kim, Kyung-Soo Abstract: Background: Recent studies have shown that microRNAs (miRNAs) are involved in the process of cardiomyocyte apoptosis. We have previously reported that granulocyte-colony stimulating factor (G-CSF) ameliorated diastolic dysfunction and attenuated cardiomyocyte apoptosis in a rat model of diabetic cardiomyopathy. In this study, we hypothesized a regulatory role of cardiac miRNAs in the mechanism of the anti-apoptotic effect of G-CSF in a diabetic cardiomyopathy rat model. Methods: Rats were given a high-fat diet and low-dose streptozotocin injection and then randomly allocated to receive treatment with either G-CSF or saline. H9c2 rat cardiomyocytes were cultured under a high glucose (HG) condition to induce diabetic cardiomyopathy in vitro. We examined the extent of apoptosis, miRNA expression, and miRNA target genes in the myocardium and H9c2 cells. Results: G-CSF treatment significantly decreased apoptosis and reduced miR-34a expression in diabetic myocardium and H9c2 cells under the HG condition. G-CSF treatment also significantly increased B-cell lymphoma 2 (Bcl-2) protein expression as a target for miR-34a. In addition, transfection with an miR-34a mimic significantly increased apoptosis and decreased Bcl-2 luciferase activity in H9c2 cells. Conclusion: Our results indicate that G-CSF might have an anti-apoptotic effect through down-regulation of miR-34a in a diabetic cardiomyopathy rat model. 2020-02-01T00:00:00Z