https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/467 2026-07-04T02:27:18Z https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/211859 Title: A decade-long comparison of depressive symptom networks in Asian patients with depressive disorders: Findings from REAP studies in 2023 and 2013 Authors: Lee, Seonjae; Kim, Han Seul; Yoon, Heechan; Kim, Eunkyung; Kim, Kiwon; Kim, Ii Bin; Yang, Hyun-Ju; Yoon, Hyung-Jun; Kim, Hyun Soo; Kim, Gyung-Mee; Si, Tian-Mei; Kallivayalil, Roy Abraham; Tanra, Andi J.; Chee, Kok Yoon; Sim, Kang; Pariwatcharakul, Pornjira; Lin, Shih-Ku; Sartorius, Norman; Shinfuku, Naotaka; Lee, Seonhwa; Toyota, Eric; Lee, Jae-Hon; Kato, Takahiro A.; Park, Seon-Cheol Abstract: Background Network analysis provides a framework for examining interrelationships among symptoms beyond traditional categorical diagnostic models. Objective Data were analyzed from two decade-apart, large-scale, multi-country surveys in Asia. Network structures of depressive symptoms among Asian patients with depressive disorders in 2023 and 2013 were compared. Methods Ten depressive symptom domains, rated by clinicians in accordance with National Institute for Health and Care Excellence (NICE) guidelines, were modeled using the graphical Least Absolute Shrinkage and Selection Operator. Network structures were compared using the Network Comparison Test and evaluated with respect to expected influence centrality, stability, and clustering. Subgroup network structure comparisons were additionally conducted according to gender and geographic region. Results The Network Comparison Test demonstrated significant differences in both network structure and global strength between 2013 and 2023. In 2023, among 2298 patients, depressive symptom networks comprised 38 connections, with the strongest associations observed between low self-confidence and guilt or self-blame and between disturbed sleep and poor or increased appetite; low self-confidence emerged as the most central symptom. In contrast, in 2013, among 1303 patients, 36 connections were identified, with persistent sadness and disturbed sleep forming the strongest association and persistent sadness representing the most central symptom. Substantial subgroup differences in network structure were also observed according to gender and region. Conclusions These differences may reflect contextual influences, including the COVID-19 pandemic and related sociocultural factors. The findings may further identify self-critical symptoms as promising targets for clinical intervention. 2026-07-01T00:00:00Z https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/211850 Title: Early-life exposure to per- and polyfluoroalkyl substances and heavy metals and lower lung function in school-age children: A prospective cohort study Authors: Shin, Sanghee; Shin, Choong Ho; Lee, Young Ah; Lee, Yun Jeong; Hong, Yun-Chul; Lim, Youn-Hee; Kim, Bung-Nyun; Kim, Johanna Inhyang; Lee, Dong-Wook; Kim, Kyoung-Nam Abstract: Previous studies examining the associations of per- and polyfluoroalkyl substances (PFAS) and heavy metals (HMs) with lung function have yielded inconsistent findings. We investigated the associations of PFAS and HMs with lung function in a Korean birth cohort followed up to 10 years of age. Data from the Environment and Development of Children (EDC) cohort were used (n = 505). Serum PFAS and whole blood HM concentrations were measured at ages 2, 4, and 6 years. Lung function was assessed at ages 8 and 10 years. Linear mixed models were used to evaluate the associations of individual chemicals with repeated lung function measurements. Principal component analysis (PCA) within a doubly robust estimation framework was applied to examine the associations between chemical mixtures and lung function. In analyses for individual chemicals, several PFAS (e.g., perfluorooctanoic acid [PFOA] and linear perfluorooctane sulfonate [L-PFOS]) and HMs (e.g., mercury and cadmium), particularly those measured at age 2, were associated with lower lung function. In mixture analyses, higher age-2 PCA-derived exposure patterns characterized by PFAS-dominant components were associated with lower FEF25-75 [β = 0.04, 95% confidence interval (CI): 0.01, 0.07], whereas higher age-2 HM-dominant components were associated with lower FEV1/FVC (β = 1.33, 95% CI: 0.63, 2.03) at 8–10 years. These findings suggest that early-life exposure to PFAS- and HM-dominant mixtures, particularly around age 2 years, may adversely influence subsequent lung function. Our results highlight the importance of early-life prevention strategies to minimize exposure to these ubiquitous chemicals, particularly around 2 years of age. 2026-06-01T00:00:00Z https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/215046 Title: 불면증에 대한 적절하고 안전한 처방 Authors: 박선철 2026-05-30T00:00:00Z https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/215045 Title: 환청의 정신병리적 이해 Authors: 박선철 2026-05-08T00:00:00Z