https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/300 Fri, 03 Jul 2026 13:56:58 GMT 2026-07-03T13:56:58Z https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/217703 Title: Rapid Spontaneous Tumor Regression Mimicking Pseudoprogression in Pembrolizumab-treated Non–small Cell Lung Cancer Authors: Yoo, Seung-Jin; Lee, Hyun; Myung, Jae Kyung; Choi, Yun Young; Lee, Soo Jin Abstract: Atypical tumor responses can occur during immune checkpoint inhibitor therapy. A 71-year-old man receiving pembrolizumab treatment for stage IV non–small cell lung cancer was found on 18F-FDG PET/CT to have developed new lesions in the stomach, left adrenal gland, and lungs. Because a gastric biopsy confirmed metastatic disease, treatment was discontinued. Remarkably, all lesions resolved after 4 weeks without any treatment. Pembrolizumab therapy was restarted, and follow-up CT showed further reduction in the lung cancer without new lesions. This case of spontaneous regression of gastric metastasis mimicking a pseudoprogression response to pembrolizumab treatment highlights the possibility of unusual presentations during immunotherapy. Fri, 01 May 2026 00:00:00 GMT https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/217703 2026-05-01T00:00:00Z https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/217692 Title: HITE: HIV Inspired Lipid Nanoparticle Platform for CAR T Cell Engineering Authors: Kim, Dongyoon; Moon, So-Jeong; Han, Emily L.; Feng, Ellie; Murray, Amanda M.; Wang, Jinjin; Liu, Wei; Kong, Gu; June, Carl H.; Mitchell, Michael J. Abstract: Chimeric antigen receptor (CAR)-T therapy has led to remarkable advancements in the treatment of hematologic malignancies, encouraging extensive studies on its application to solid tumors and other diseases. However, the production of CAR-T cells is mostly achieved through viral transduction, which results in permanent CAR expression in T cells, potentially leading to unintended adverse effects. Here, we present a lipid nanoparticle (LNP) platform for mRNA delivery to human primary T cells, inspired by the human immunodeficiency virus (HIV) which naturally infects T cells. We perform multiple rounds of screening to sequentially optimize the structure and ratio of ionizable lipid in the base formulation, the ratios of HIV lipid components, and the type and ratio of PEG-lipid for CD3 antibody conjugation. Our HIV envelope-Inspired T cell transfection-Enhancing (HITE) LNP enables efficient generation of CAR-T cells with potent cytotoxic activity against cancer cells in vitro, demonstrating its potential for efficient CAR-T cell production. Fri, 01 May 2026 00:00:00 GMT https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/217692 2026-05-01T00:00:00Z https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/212927 Title: Primary extracranial meningioma of the temporal region: a case report and literature review Authors: Jung, Jae-A; Park, Sang Hyun; Oh, Young-Ha; Chang, Jungwoo Abstract: Meningioma arises from arachnoid cap cells and is a common intracranial neoplasm; however, primary extracranial meningioma is rare, accounting for only 1%–2% of cases and is therefore frequently misdiagnosed. We report a case of primary extracranial meningioma arising in the temporal region without intracranial or dural involvement. A 66-year-old woman presented with a slowly enlarging mass in the left temporal region for approximately 10 years, without pain or limitation of mouth opening. Computed tomography revealed a 2.1× 2.7× 4.6 cm mass between the temporalis muscle and the skull, with no intracranial extension. Fine-needle aspiration suggested a spindle-cell neoplasm, and complete excision was performed via a coronal scalp incision for diagnosis and treatment. Histopathologic and immunohistochemical examination confirmed a World Health Organization grade II extracranial meningioma. The patient recovered without complications. Postoperative magnetic resonance imaging showed no residual tumor, and adjuvant radiotherapy was not administered. Surveillance imaging every 6 months demonstrated no recurrence over 3.5 years. This case highlights the importance of including extracranial meningioma in the differential diagnosis of temporal masses and supports complete excision as effective management. A brief literature review is included. Wed, 01 Apr 2026 00:00:00 GMT https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/212927 2026-04-01T00:00:00Z https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/211887 Title: Absence of AMPK expression is an independent risk factor for stage II/III colorectal cancer recurrence Authors: Goh, Hyun Seok; Park, Sung Sil; Kim, Hyun Sung; Ahn, Byung Kyu Abstract: [No abstract available] Wed, 01 Apr 2026 00:00:00 GMT https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/211887 2026-04-01T00:00:00Z