https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/324 Fri, 24 Jul 2026 09:20:09 GMT 2026-07-24T09:20:09Z https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/213821 Title: Changes in alcohol consumption and their association with lipid profiles among Korean adults aged 40-69 years: the Korea Genome and Epidemiology Study Authors: Park, Sohyun; Park, Boyoung Abstract: Background and aim: Alcohol consumption influences lipid profiles and cardiovascular risk; however, the longitudinal effects of changes in drinking behavior on serum lipid levels remain unclear. This study evaluated associations between alcohol initiation and cessation and changes in lipid profiles among Korean adults. Methods and results: We analyzed data from the community-based Korean Genome and Epidemiology Study (KoGES), including adults aged 40-69 years. Changes in low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides, and total cholesterol were assessed across follow-up visits. Associations between changes in alcohol intake—initiation, cessation, and average number of standard drinks per day—and lipid changes were estimated using generalized estimating equations adjusted for demographic, lifestyle, and clinical factors. Compared with individuals who remained non-consumers, alcohol initiation was associated with increased HDL-C levels (β = 1.07; 95% CI, 0.60 to 1.55; p < 0.001), with no significant change in LDL-C. Compared with continued consumers, alcohol cessation was associated with decreased HDL-C (β = −2.37; 95% CI, −3.80 to −1.94; p < 0.001), triglycerides (β = −2.92; 95% CI, −5.81 to −0.02; p = 0.049), and total cholesterol (β = −2.30; 95% CI, −3.80 to −0.79; p = 0.003). Each one-standard drink/day increase was associated with higher HDL-C (β = 0.94; 95% CI, 0.51 to 1.36; p < 0.001) and lower LDL-C (β = −0.87; 95% CI, −1.68 to −0.05; p = 0.037). Conclusions: Alcohol initiation and cessation were associated with distinct lipid changes, highlighting metabolic implications of drinking patterns and supporting moderation in alcohol consumption. Wed, 01 Jul 2026 00:00:00 GMT https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/213821 2026-07-01T00:00:00Z https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/219446 Title: Trends in cancer incidence among people with human immunodeficiency virus in South Korea: a nationwide National Health Insurance Service data-based study Authors: Jeong, Yeon Jeong; Kim, Youn Jeong; Kim, Sang Il; Jun, Yoon Hee; Park, Boyoung; Choi, Yunsu; Choi, Jun Yong; Kim, Jung Ho; Kim, Hyo Youl; Sohn, Jang Wook; Song, Joon Young; Kim, Shin-Woo; Kim, YeonJae; Choi, Hee Jung Abstract: Background The application of antiretroviral therapy (ART) in people with human immunodeficiency virus (PWH) has led to a shift in cancer epidemiology. Methods PWH were selected from the National Health Insurance Service database from 2002 to 2018. Cancers were identified using the Korean Classification of Disease cancer codes from 2004 to 2019. For incidence analyses, only the first recorded cancer diagnosis per individual was considered. The trends in cancer epidemiology were analyzed according to the duration since HIV diagnosis, categorized as 0–3 years (duration 1), 4–7 years (duration 2), 8–11 years (duration 3), and 12–15 years (duration 4). Analyses were also stratified by the period before and after the implementation of expanded cancer screening programs in Korea: 2004–2011 (period 1) and 2012–2019 (period 2). Results Among 15,110 PWH, 774 developed cancers during follow-up. Of these, 241 were ADCs (234.26 per 100,000 person-years) and 533 were NADCs (523.08 per 100,000 person-years). The proportion of ADCs among all cancers was 37.1%, 21.1%, 20.0%, and 13.5% across increasing durations since HIV diagnosis. Conclusions In the ART era, NADCs represent an increasing disease burden in PWH, underscoring the importance of cancer screening following HIV diagnosis. Mon, 01 Jun 2026 00:00:00 GMT https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/219446 2026-06-01T00:00:00Z https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/219451 Title: Association between EMS response time and return of spontaneous circulation in out-of-hospital cardiac arrest patients in Busan, South Korea Authors: Kwon, Hye-ji; Shin, Young-jeon Abstract: Objectives: This study evaluated the impact of response time on prehospital return of spontaneous circulation (ROSC) in out-of-hospital cardiac arrest (OHCA) patients in Busan, South Korea. Methods: We analyzed OHCA cases from Busan Fire and Disaster Headquarters (January–December 2022). A total of 2388 patients aged ≥18 years with complete EMS records were included. After excluding response time groups with <30 observations, 2268 cases were analyzed using SAS 9.4 for multiple logistic regression. Results: Among 2388 OHCA patients in Busan, 179 (7.5 %) achieved ROSC. Only 2.5 % of cases met the 4-min response time benchmark. Multiple logistic regression identified key factors associated with higher ROSC: younger age (OR = 3.650 for 18–60 years vs. oldest group), witnessed arrest (OR = 2.788), shockable rhythm (OR = 3.105), bystander CPR (OR = 1.881), and EMS defibrillation (OR = 4.554). Response time showed the strongest association at <4 min (OR = 2.812), declining progressively at 5 min (OR = 1.748), 6 min (OR = 1.339), and 7 min (OR = 1.146). Conclusions: Shorter response times were associated with increased ROSC rates in OHCA patients. This highlights the need for policy measures to reduce response times, including community-based early recognition systems and optimized emergency resource allocation. Mon, 01 Jun 2026 00:00:00 GMT https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/219451 2026-06-01T00:00:00Z https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/210928 Title: Assessing the safety of herbal medicine use among type 2 diabetes mellitus patients: A systematic review and meta-analysis Authors: Boulares, Emna; Bragazzi, Nicola Luigi; Yin, Tan Sabrina Chen; Choi, Soo Jeung; Park, Jung Hwan; Han, Dongwoon Abstract: Background Herbal medicines (HM) use among type 2 diabetes mellitus (T2DM) patients has grown tremendously despite the existence of conventional treatments. However, evidence on their safety, potential side effects, and interactions remains scarce. This systematic review and meta-analysis aim to determine the global prevalence of HM use among T2DM patients and assess the safety and potential interactions. Methods A systematic search of four electronic databases was conducted until March 2024. Data were extracted and then assessed through an adapted quality appraisal tool. A meta-analysis estimated the pooled prevalence of HM use among T2DM patients and examined predictors of use. Identified herbs were classified based on safety and potential interactions with pharmacological treatments. The study followed PRISMA guidelines. Results Twenty-two cross-sectional studies from 19 countries were included. The global prevalence of HM use among T2DM patients was 53%, with significant regional variations. The highest prevalence of HM use among T2DM patients is in the African region, accounting for 39.8% of global HM use. Among 49 identified herbs, Opuntia ficus-indica L., Trigonella foenum graecum L. , Allium sativum L. , and Cinnamomum verum J . were the most commonly used. The safety classification reported 7 contraindicated herbs and 19 requiring caution, and 23 considered safe for use. Additionally, 12 herbs reported potential pharmacological interactions. Conclusions Although the use of HM is widespread globally, multiple herbs pose safety concerns. Therefore, to preserve patients’ safety, it is essential to avoid using contraindicated herbs and to seek healthcare practitioner supervision. Fri, 01 May 2026 00:00:00 GMT https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/210928 2026-05-01T00:00:00Z