Bedside risk-scoring model for predicting 6-week mortality in cirrhotic patients undergoing endoscopic band ligation for acute variceal bleeding
DC Field | Value | Language |
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dc.contributor.author | Kim, Jung Hee | - |
dc.contributor.author | Park, Se Woo | - |
dc.contributor.author | Jung, Jang Han | - |
dc.contributor.author | Park, Da Hae | - |
dc.contributor.author | Bang, Chang Seok | - |
dc.contributor.author | Park, Chan Hyuk | - |
dc.contributor.author | Park, Ji Won | - |
dc.contributor.author | Park, Jae Gun | - |
dc.date.accessioned | 2021-07-30T04:43:06Z | - |
dc.date.available | 2021-07-30T04:43:06Z | - |
dc.date.created | 2021-07-14 | - |
dc.date.issued | 2021-07 | - |
dc.identifier.issn | 0815-9319 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/1006 | - |
dc.description.abstract | Background and Aim Acute variceal bleeding (AVB) is a fatal adverse event of cirrhosis, and endoscopic band ligation (EBL) is the standard treatment for AVB. We developed a novel bedside risk-scoring model to predict the 6-week mortality in cirrhotic patients undergoing EBL for AVB. Methods Cox regression analysis was used to assess the relationship of clinical, biological, and endoscopic variables with the 6-week mortality risk after EBL in a derivation cohort (n = 1373). The primary outcome was the predictive accuracy of the new model for the 6-week mortality in the validation cohort. Moreover, we tested the adequacy of the mortality risk-based stratification and the discriminative performance of our new model in comparison with the Child-Turcotte-Pugh (CTP) and the model for end-stage liver disease scores in the validation cohort (n = 200). Results On multivariate Cox regression analysis, five objective variables (use of beta-blockers, hepatocellular carcinoma, CTP class C, hypovolemic shock at initial presentation, and history of hepatic encephalopathy) were scored to generate a 12-point risk-prediction model. The model stratified the 6-week mortality risk in patients as low (3.5%), intermediate (21.1%), and high (53.4%) (P < 0.001). Time-dependent area under the receiver operating characteristic curve for 6-week mortality showed that this model was a better prognostic indicator than the CTP class alone in the derivation (P < 0.001) and validation (P < 0.001) cohorts. Conclusions A simplified scoring model with high potential for generalization refines the prediction of 6-week mortality in high-risk cirrhotic patients, thereby aiding the targeting and individualization of treatment strategies for decreasing the mortality rate. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.title | Bedside risk-scoring model for predicting 6-week mortality in cirrhotic patients undergoing endoscopic band ligation for acute variceal bleeding | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, Chan Hyuk | - |
dc.identifier.doi | 10.1111/jgh.15426 | - |
dc.identifier.scopusid | 2-s2.0-85102462742 | - |
dc.identifier.wosid | 000626976900001 | - |
dc.identifier.bibliographicCitation | JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, v.36, no.7, pp.1935 - 1943 | - |
dc.relation.isPartOf | JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY | - |
dc.citation.title | JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY | - |
dc.citation.volume | 36 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 1935 | - |
dc.citation.endPage | 1943 | - |
dc.type.rims | ART | - |
dc.type.docType | Article; Early Access | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Gastroenterology & Hepatology | - |
dc.relation.journalWebOfScienceCategory | Gastroenterology & Hepatology | - |
dc.subject.keywordPlus | VENOUS-PRESSURE GRADIENT | - |
dc.subject.keywordPlus | PORTAL-HYPERTENSION | - |
dc.subject.keywordPlus | CONSENSUS WORKSHOP | - |
dc.subject.keywordPlus | STRATIFYING RISK | - |
dc.subject.keywordPlus | PROGNOSTIC VALUE | - |
dc.subject.keywordPlus | MANAGEMENT | - |
dc.subject.keywordPlus | HEMORRHAGE | - |
dc.subject.keywordPlus | DIAGNOSIS | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordAuthor | Band ligation | - |
dc.subject.keywordAuthor | Mortality | - |
dc.subject.keywordAuthor | Risk | - |
dc.subject.keywordAuthor | Score | - |
dc.subject.keywordAuthor | Variceal bleeding | - |
dc.identifier.url | https://onlinelibrary.wiley.com/doi/10.1111/jgh.15426 | - |
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