Novel Enzymatic Crosslinking-based Hydrogel Nanofilm Caging System on Pancreatic β-cell Spheroid for Long-term Blood Glucose Regulation
DC Field | Value | Language |
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dc.contributor.author | Kim, Minji | - |
dc.contributor.author | Kim, Hyunbum | - |
dc.contributor.author | Lee, Young-sun | - |
dc.contributor.author | Lee, Sangjun | - |
dc.contributor.author | Kim, Seong-Eun | - |
dc.contributor.author | Lee, Uk-Jae | - |
dc.contributor.author | Jung, Sungwon | - |
dc.contributor.author | Park, Chung-Gyu | - |
dc.contributor.author | Hong, Jinkee | - |
dc.contributor.author | Doh, Junsang | - |
dc.contributor.author | Lee, Dong Yun | - |
dc.contributor.author | Kim, Byung-Gee | - |
dc.contributor.author | Hwang, Nathaniel S. | - |
dc.date.accessioned | 2021-07-30T04:43:10Z | - |
dc.date.available | 2021-07-30T04:43:10Z | - |
dc.date.created | 2021-07-15 | - |
dc.date.issued | 2021-06 | - |
dc.identifier.issn | 2375-2548 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/1025 | - |
dc.description.abstract | Pancreatic β cell therapy for type 1 diabetes is limited by low cell survival rate owing to physical stress and aggressive host immune response. In this study, we demonstrate a multilayer hydrogel nanofilm caging strategy capable of protecting cells from high shear stress and reducing immune response by interfering cell-cell interaction. Hydrogel nanofilm is fabricated by monophenol-modified glycol chitosan and hyaluronic acid that cross-link each other to form a nanothin hydrogel film on the cell surface via tyrosinase-mediated reactions. Furthermore, hydrogel nanofilm formation was conducted on mouse β cell spheroids for the islet transplantation application. The cytoprotective effect against physical stress and the immune protective effect were evaluated. Last, caged mouse β cell spheroids were transplanted into the type 1 diabetes mouse model and successfully regulated its blood glucose level. Overall, our enzymatic cross-linking–based hydrogel nanofilm caging method will provide a new platform for clinical applications of cell-based therapies. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | AMER ASSOC ADVANCEMENT SCIENCE | - |
dc.title | Novel Enzymatic Crosslinking-based Hydrogel Nanofilm Caging System on Pancreatic β-cell Spheroid for Long-term Blood Glucose Regulation | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Dong Yun | - |
dc.identifier.doi | 10.1126/sciadv.abf7832 | - |
dc.identifier.scopusid | 2-s2.0-85108721797 | - |
dc.identifier.wosid | 000664978800017 | - |
dc.identifier.bibliographicCitation | SCIENCE ADVANCES, v.7, no.26, pp.1 - 10 | - |
dc.relation.isPartOf | SCIENCE ADVANCES | - |
dc.citation.title | SCIENCE ADVANCES | - |
dc.citation.volume | 7 | - |
dc.citation.number | 26 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 10 | - |
dc.type.rims | ART | - |
dc.type.docType | 정기학술지(Article(Perspective Article포함)) | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | ISLET ENCAPSULATION | - |
dc.subject.keywordPlus | SINGLE CELLS | - |
dc.subject.keywordPlus | TECHNOLOGIES | - |
dc.subject.keywordPlus | POLYPHENOL | - |
dc.subject.keywordPlus | TYROSINASE | - |
dc.identifier.url | https://www.science.org/doi/10.1126/sciadv.abf7832 | - |
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