Effect of Human Mesenchymal Stem Cells on Xenogeneic T and B Cells Isolated from Lupus-Prone MRL.Fas(lpr) Mice
DC Field | Value | Language |
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dc.contributor.author | Lee, Hong Kyung | - |
dc.contributor.author | Kim, Eun Young | - |
dc.contributor.author | Kim, Hyung Sook | - |
dc.contributor.author | Park, Eun Jae | - |
dc.contributor.author | Lee, Hye Jin | - |
dc.contributor.author | Lee, Tae Yong | - |
dc.contributor.author | Kim, Kyung Suk | - |
dc.contributor.author | Bae, Sang-Cheol | - |
dc.contributor.author | Hong, Jin Tae | - |
dc.contributor.author | Kim, Youngsoo | - |
dc.contributor.author | Han, Sang-Bae | - |
dc.date.accessioned | 2021-08-02T09:52:11Z | - |
dc.date.available | 2021-08-02T09:52:11Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2020-03 | - |
dc.identifier.issn | 1687-966X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/10643 | - |
dc.description.abstract | Systemic lupus erythematosus (SLE) is an autoimmune disease, which is characterized by hyperactivation of T and B cells. Human mesenchymal stem cells (hMSCs) ameliorate the progression of SLE in preclinical studies using lupus-prone MRL.Fas(lpr) mice. However, whether hMSCs inhibit the functions of xenogeneic mouse T and B cells is not clear. To address this issue, we examined the in vitro effects of hMSCs on T and B cells isolated from MRL.Fas(lpr) mice. Naive hMSCs inhibited the functions of T cells but not B cells. hMSCs preconditioned with IFN-gamma (i) inhibited the proliferation of and IgM production by B cells, (ii) attracted B cells for cell-cell interactions in a CXCL10-dependent manner, and (iii) inhibited B cells by producing indoleamine 2,3-dioxygenase. In summary, our data demonstrate that hMSCs exert therapeutic activity in mice in three steps: first, naive hMSCs inhibit the functions of T cells, hMSCs are then activated by IFN-gamma, and finally, they inhibit B cells. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | HINDAWI LTD | - |
dc.title | Effect of Human Mesenchymal Stem Cells on Xenogeneic T and B Cells Isolated from Lupus-Prone MRL.Fas(lpr) Mice | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Bae, Sang-Cheol | - |
dc.identifier.doi | 10.1155/2020/5617192 | - |
dc.identifier.scopusid | 2-s2.0-85082326378 | - |
dc.identifier.wosid | 000522404500001 | - |
dc.identifier.bibliographicCitation | STEM CELLS INTERNATIONAL, v.2020, pp.1 - 10 | - |
dc.relation.isPartOf | STEM CELLS INTERNATIONAL | - |
dc.citation.title | STEM CELLS INTERNATIONAL | - |
dc.citation.volume | 2020 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 10 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Cell & Tissue Engineering | - |
dc.subject.keywordPlus | INTERFERON-GAMMA | - |
dc.subject.keywordPlus | ANTIBODY-PRODUCTION | - |
dc.subject.keywordPlus | STROMAL CELLS | - |
dc.subject.keywordPlus | PROLIFERATION | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | MODEL | - |
dc.subject.keywordPlus | 2,3-DIOXYGENASE | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | FAIL | - |
dc.identifier.url | https://www.hindawi.com/journals/sci/2020/5617192/ | - |
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