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Effect of Human Mesenchymal Stem Cells on Xenogeneic T and B Cells Isolated from Lupus-Prone MRL.Fas(lpr) Mice

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dc.contributor.authorLee, Hong Kyung-
dc.contributor.authorKim, Eun Young-
dc.contributor.authorKim, Hyung Sook-
dc.contributor.authorPark, Eun Jae-
dc.contributor.authorLee, Hye Jin-
dc.contributor.authorLee, Tae Yong-
dc.contributor.authorKim, Kyung Suk-
dc.contributor.authorBae, Sang-Cheol-
dc.contributor.authorHong, Jin Tae-
dc.contributor.authorKim, Youngsoo-
dc.contributor.authorHan, Sang-Bae-
dc.date.accessioned2021-08-02T09:52:11Z-
dc.date.available2021-08-02T09:52:11Z-
dc.date.created2021-05-12-
dc.date.issued2020-03-
dc.identifier.issn1687-966X-
dc.identifier.urihttps://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/10643-
dc.description.abstractSystemic lupus erythematosus (SLE) is an autoimmune disease, which is characterized by hyperactivation of T and B cells. Human mesenchymal stem cells (hMSCs) ameliorate the progression of SLE in preclinical studies using lupus-prone MRL.Fas(lpr) mice. However, whether hMSCs inhibit the functions of xenogeneic mouse T and B cells is not clear. To address this issue, we examined the in vitro effects of hMSCs on T and B cells isolated from MRL.Fas(lpr) mice. Naive hMSCs inhibited the functions of T cells but not B cells. hMSCs preconditioned with IFN-gamma (i) inhibited the proliferation of and IgM production by B cells, (ii) attracted B cells for cell-cell interactions in a CXCL10-dependent manner, and (iii) inhibited B cells by producing indoleamine 2,3-dioxygenase. In summary, our data demonstrate that hMSCs exert therapeutic activity in mice in three steps: first, naive hMSCs inhibit the functions of T cells, hMSCs are then activated by IFN-gamma, and finally, they inhibit B cells.-
dc.language영어-
dc.language.isoen-
dc.publisherHINDAWI LTD-
dc.titleEffect of Human Mesenchymal Stem Cells on Xenogeneic T and B Cells Isolated from Lupus-Prone MRL.Fas(lpr) Mice-
dc.typeArticle-
dc.contributor.affiliatedAuthorBae, Sang-Cheol-
dc.identifier.doi10.1155/2020/5617192-
dc.identifier.scopusid2-s2.0-85082326378-
dc.identifier.wosid000522404500001-
dc.identifier.bibliographicCitationSTEM CELLS INTERNATIONAL, v.2020, pp.1 - 10-
dc.relation.isPartOfSTEM CELLS INTERNATIONAL-
dc.citation.titleSTEM CELLS INTERNATIONAL-
dc.citation.volume2020-
dc.citation.startPage1-
dc.citation.endPage10-
dc.type.rimsART-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.isOpenAccessY-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaCell Biology-
dc.relation.journalWebOfScienceCategoryCell & Tissue Engineering-
dc.subject.keywordPlusINTERFERON-GAMMA-
dc.subject.keywordPlusANTIBODY-PRODUCTION-
dc.subject.keywordPlusSTROMAL CELLS-
dc.subject.keywordPlusPROLIFERATION-
dc.subject.keywordPlusINHIBITION-
dc.subject.keywordPlusMODEL-
dc.subject.keywordPlus2,3-DIOXYGENASE-
dc.subject.keywordPlusDIFFERENTIATION-
dc.subject.keywordPlusFAIL-
dc.identifier.urlhttps://www.hindawi.com/journals/sci/2020/5617192/-
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