NFAT-Specific Inhibition by dNP2-VIVIT Ameliorates Autoimmune Encephalomyelitis by Regulation of Th1 and Th17
DC Field | Value | Language |
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dc.contributor.author | Lee, Hong-Gyun | - |
dc.contributor.author | Kim, Li-Kyung | - |
dc.contributor.author | Choi, Je-Min | - |
dc.date.accessioned | 2021-08-02T09:52:16Z | - |
dc.date.available | 2021-08-02T09:52:16Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2020-03 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/10649 | - |
dc.description.abstract | Nuclear factor of activated T cells (NFATs) is an important transcription factor for T cell activation and proliferation. Recent studies have highlighted the role of NFATs in regulating the differentiation of effector CD4 T helper (Th) subsets including Th1 and Th17 cells. Because controlling the effector T cell function is important for the treatment of autoimmune diseases, regulation of NFAT functions in T cells would be an important strategy to control the pathogenesis of autoimmune diseases. Here, we demonstrated that an NFAT inhibitory peptide, VIVIT conjugated to dNP2 (dNP2-VIVIT), a bloodbrain barrier-permeable peptide, ameliorated experimental autoimmune encephalomyelitis (EAE) by inhibiting Th 1 and Th17 cells, but not regulatory T (T-reg) cells. dNP2-VIVIT negatively regulated spinal cord-infiltrating interleukin-17A (IL17A) and interferon (IFN)-gamma-producing CD4(+ )T cells without affecting the number of Foxp3(+) CD4(+) T reg cells, whereas dNP2-VEET or 11R-VIVIT could not significantly inhibit EAE. In comparison with cyclosporin A (CsA), dNP2-VIVIT selectively inhibited Thl and Th17 differentiation, whereas CsA inhibited the differentiation of all T cell subsets including that of Th2 and T reg cells. Collectively, this study demonstrated the role of dNP2-VIVIT as a novel agent for the treatment of autoimmune diseases such as multiple sclerosis by regulating the functions of Th1 and Th17 cells. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | CELL PRESS | - |
dc.title | NFAT-Specific Inhibition by dNP2-VIVIT Ameliorates Autoimmune Encephalomyelitis by Regulation of Th1 and Th17 | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Choi, Je-Min | - |
dc.identifier.doi | 10.1016/j.omtm.2019.10.006 | - |
dc.identifier.scopusid | 2-s2.0-85074464258 | - |
dc.identifier.wosid | 000519942400004 | - |
dc.identifier.bibliographicCitation | MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT, v.16, pp.32 - 41 | - |
dc.relation.isPartOf | MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT | - |
dc.citation.title | MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT | - |
dc.citation.volume | 16 | - |
dc.citation.startPage | 32 | - |
dc.citation.endPage | 41 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.subject.keywordPlus | T-CELL-ACTIVATION | - |
dc.subject.keywordPlus | CIS-TRANS ISOMERASE | - |
dc.subject.keywordPlus | CYCLOSPORINE-A | - |
dc.subject.keywordPlus | CALCINEURIN INHIBITORS | - |
dc.subject.keywordPlus | NUCLEAR FACTOR | - |
dc.subject.keywordPlus | TRANSCRIPTION | - |
dc.subject.keywordPlus | RESPONSES | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordPlus | BINDING | - |
dc.subject.keywordPlus | TACROLIMUS | - |
dc.subject.keywordAuthor | Cell penetrating peptide (CPP) | - |
dc.subject.keywordAuthor | dNP2 | - |
dc.subject.keywordAuthor | Multiple sclerosis (MS) | - |
dc.subject.keywordAuthor | T cell | - |
dc.subject.keywordAuthor | VIVIT | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S2329050119301147?via%3Dihub | - |
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