HL301 versus Umckamin in the treatment of acute bronchitis: a phase III, randomized, controlled, double-blind, multicenter study
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Won-Young | - |
dc.contributor.author | Park, Myung Jae | - |
dc.contributor.author | Rhee, Chin Kook | - |
dc.contributor.author | Lee, Sang Yeub | - |
dc.contributor.author | Kim, Jin | - |
dc.contributor.author | Kim, Dong Gyu | - |
dc.contributor.author | Choi, Chang-Min | - |
dc.contributor.author | Kim, Deog Kyeom | - |
dc.contributor.author | Kim, Yee Hyung | - |
dc.contributor.author | Yoon, Ho Joo | - |
dc.contributor.author | Kim, Jae Yeol | - |
dc.date.accessioned | 2021-08-02T09:53:03Z | - |
dc.date.available | 2021-08-02T09:53:03Z | - |
dc.date.created | 2021-05-11 | - |
dc.date.issued | 2020-03 | - |
dc.identifier.issn | 0300-7995 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/10699 | - |
dc.description.abstract | Objective: HL301 is a combination product of seven medicinal plants that has been proven effective in acute bronchitis by two phase II studies. In the present study, its efficacy and safety compared with those of Umckamin in the treatment of acute bronchitis were evaluated in phase III, randomized, controlled, double-blind, multicenter trial design. Methods: A total of 246 acute bronchitis patients were randomized to receive either HL301 (600 mg/day) or Umckamin (333 mg/day) for seven days. The primary outcome was the difference in their baseline (visit 2) and end of treatment (visit 3) bronchitis severity score (BSS). Other efficacy variables included the change in each BSS component (cough, sputum, dyspnea, chest pain, and crackle), response rate, improvement rate, and satisfaction rate with treatment. Results: A full analysis set and per protocol set analysis of both groups revealed that the difference of BSS between visit 2 and visit 3 in the HL301 and Umckamin group was not significantly different (4.58 ± 1.79 versus 4.29 ± 1.88, p = .37 and 4.60 ± 1.81 versus 4.33 ± 1.88, p = .42, respectively). The change in five BSS components (cough, sputum, dyspnea, chest pain, and crackle) of the HL301 and Umckamin groups did not differ after treatment. HL301 or Umckamin treated participants showed an equal level of response, improvement, and satisfaction rates with treatment. Both the HL301 group and Umckamin group showed the same safety profile. Conclusions: HL301 (600 mg/day) was as effective and safe as Umckamin (333 mg/day) in treating acute bronchitis. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | TAYLOR & FRANCIS LTD | - |
dc.title | HL301 versus Umckamin in the treatment of acute bronchitis: a phase III, randomized, controlled, double-blind, multicenter study | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Yoon, Ho Joo | - |
dc.identifier.doi | 10.1080/03007995.2019.1706044 | - |
dc.identifier.scopusid | 2-s2.0-85078618237 | - |
dc.identifier.wosid | 000519343700019 | - |
dc.identifier.bibliographicCitation | CURRENT MEDICAL RESEARCH AND OPINION, v.36, no.3, pp.503 - 508 | - |
dc.relation.isPartOf | CURRENT MEDICAL RESEARCH AND OPINION | - |
dc.citation.title | CURRENT MEDICAL RESEARCH AND OPINION | - |
dc.citation.volume | 36 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 503 | - |
dc.citation.endPage | 508 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.subject.keywordPlus | RESPIRATORY-TRACT INFECTION | - |
dc.subject.keywordPlus | MURINE MODEL | - |
dc.subject.keywordPlus | EFFICACY | - |
dc.subject.keywordPlus | PNEUMONIA | - |
dc.subject.keywordPlus | SAFETY | - |
dc.subject.keywordAuthor | HL301 | - |
dc.subject.keywordAuthor | Umckamin | - |
dc.subject.keywordAuthor | acute bronchitis | - |
dc.subject.keywordAuthor | bronchitis severity score | - |
dc.identifier.url | https://www.tandfonline.com/doi/full/10.1080/03007995.2019.1706044 | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
222, Wangsimni-ro, Seongdong-gu, Seoul, 04763, Korea+82-2-2220-1365
COPYRIGHT © 2021 HANYANG UNIVERSITY.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.