Assessment of Inflammation in Pulmonary Artery Hypertension by 68Ga-Mannosylated Human Serum Albumin
DC Field | Value | Language |
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dc.contributor.author | Park, Jun-Bean | - |
dc.contributor.author | Suh, Minseok | - |
dc.contributor.author | Park, Ji Yong | - |
dc.contributor.author | Park, Jin Kyun | - |
dc.contributor.author | Kim, Yong-il | - |
dc.contributor.author | Kim, Hyunah | - |
dc.contributor.author | Cho, Ye Seul | - |
dc.contributor.author | Kang, Hyejeong | - |
dc.contributor.author | Kim, Kibyung | - |
dc.contributor.author | Choi, Jae-Hoon | - |
dc.contributor.author | Nam, Jin-Wu | - |
dc.contributor.author | Kim, Hyung-Kwan | - |
dc.contributor.author | Lee, Yun-Sang | - |
dc.contributor.author | Jeong, Jae Min | - |
dc.contributor.author | Kim, Yong-Jin | - |
dc.contributor.author | Paeng, Jin Chul | - |
dc.contributor.author | Lee, Seung-Pyo | - |
dc.date.accessioned | 2021-08-02T10:25:52Z | - |
dc.date.available | 2021-08-02T10:25:52Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2020-01 | - |
dc.identifier.issn | 1073-449X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/11428 | - |
dc.description.abstract | Rationale: Diagnosis and monitoring of patients with pulmonary artery hypertension (PAH) is currently difficult. Objectives: We aimed to develop a noninvasive imaging modality for PAH that tracks the infiltration of macrophages into the pulmonary vasculature, using a positron emission tomography (PET) agent, Ga-68-2-(p-isothiocyanatobenzyl)-1,4,7-triazacyclononane-1,4,7-triacetic acid (NOTA) mannosylated human serum albumin (MSA), that targets the mannose receptor (MR). Methods: We induced PAH in rats by monocrotaline injection. Tissue analysis, echocardiography, and Ga-68-NOTA-MSA PET were performed weekly in rats after monocrotaline injection and in those treated with either sildenafil or macitentan. The translational potential of Ga-68-NOTA-MSA PET was explored in patients with PAH. Measurements and Main Results: Gene sets related to macrophages were significantly enriched on whole transcriptome sequencing of the lung tissue in PAH rats. Serial PET images of PAH rats demonstrated increasing uptake of Ga-68-NOTA-MSA in the lung by time that corresponded with the MR-positive macrophage recruitment observed in immunohistochemistry. In sildenafil- or macitentan-treated PAH rats, the infiltration of MR-positive macrophages by histology and the uptake of Ga-68-NOTA-MSA on PET was significantly lower than that of the PAH-only group. The pulmonary uptake of Ga-68-NOTA-MSA was significantly higher in patients with PAH than normal subjects (P = 0.009) or than those with pulmonary hypertension by left heart disease (P = 0.019) (n = 5 per group). Conclusions: Ga-68-NOTA-MSA PET can help diagnose PAH and monitor the inflammatory status by imaging the degree of macrophage infiltration into the lung. These observations suggest that Ga-68-NOTA-MSA PET has the potential to be used as a novel noninvasive diagnostic and monitoring tool of PAH. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | AMER THORACIC SOC | - |
dc.title | Assessment of Inflammation in Pulmonary Artery Hypertension by 68Ga-Mannosylated Human Serum Albumin | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Choi, Jae-Hoon | - |
dc.contributor.affiliatedAuthor | Nam, Jin-Wu | - |
dc.identifier.doi | 10.1164/rccm.201903-0639OC | - |
dc.identifier.scopusid | 2-s2.0-85076794966 | - |
dc.identifier.wosid | 000505158800017 | - |
dc.identifier.bibliographicCitation | AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, v.201, no.1, pp.95 - 106 | - |
dc.relation.isPartOf | AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE | - |
dc.citation.title | AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE | - |
dc.citation.volume | 201 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 95 | - |
dc.citation.endPage | 106 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalResearchArea | Respiratory System | - |
dc.relation.journalWebOfScienceCategory | Critical Care Medicine | - |
dc.relation.journalWebOfScienceCategory | Respiratory System | - |
dc.subject.keywordPlus | POSITRON-EMISSION-TOMOGRAPHY | - |
dc.subject.keywordPlus | INDUCED MITOGENIC FACTOR | - |
dc.subject.keywordPlus | SOLUBLE CD163 | - |
dc.subject.keywordPlus | ATHEROSCLEROSIS | - |
dc.subject.keywordPlus | PATHOGENESIS | - |
dc.subject.keywordPlus | LUNG | - |
dc.subject.keywordPlus | RECRUITMENT | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | ENDOTHELIN | - |
dc.subject.keywordPlus | MANAGEMENT | - |
dc.subject.keywordAuthor | pulmonary artery hypertension | - |
dc.subject.keywordAuthor | molecular imaging | - |
dc.subject.keywordAuthor | macrophage | - |
dc.subject.keywordAuthor | diagnosis | - |
dc.subject.keywordAuthor | monitoring | - |
dc.identifier.url | https://www.atsjournals.org/doi/10.1164/rccm.201903-0639OC | - |
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