Role of innate lymphoid cells in chronic colitis during anti-IL-17A therapy
DC Field | Value | Language |
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dc.contributor.author | Park, Chan Hyuk | - |
dc.contributor.author | Lee, A-reum | - |
dc.contributor.author | Ahn, Sang Bong | - |
dc.contributor.author | Eun, Chang Soo | - |
dc.contributor.author | Han, Dong Soo | - |
dc.date.accessioned | 2021-08-02T10:27:01Z | - |
dc.date.available | 2021-08-02T10:27:01Z | - |
dc.date.created | 2021-05-11 | - |
dc.date.issued | 2020-01 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/11511 | - |
dc.description.abstract | IL-17A is an important cytokine in intestinal inflammation. However, anti-IL-17A therapy does not improve clinical outcomes in patients with Crohn's disease. We aimed to evaluate the role of ROR gamma t(+) innate lymphoid cells (ILCs) in murine colitis models in the absence of IL-17A. An acute colitis model was induced with either dextran sulfate sodium (DSS) or trinitrobenzenesulfonic acid (TNBS) and a chronic colitis model was induced by CD4(+)CD45RB(hi) T cell transfer from either wild-type C57BL/6 or Il17a(-/-) mice. An anti-IL-17A antibody, secukinumab, was also used to inhibit IL-17A function in the colitis model. Flow cytometry was performed to analyze the population of ROR gamma t(+) ILCs in the colonic lamina propria of mice with chronic colitis. Acute intestinal inflammation due to DSS and TNBS was attenuated in IL-17A knockout mice, whereas chronic colitis was not relieved by T cell transfer from Il17a(-/-) mice (% of original body weight: wild-type mice vs. Il17a(-/-) mice, 81.9% vs. 82.2%; P = 0.922). However, the mean proportion of Lin-ROR gamma t(+) lymphocytes was higher after T cell transfer from Il17a(-/-) mice than that after T cell transfer from wild-type mice (28.8% vs. 18.5%). The proportion of Lin-ROR gamma t(+) was also increased in Rag2(-/-) mice that received T cell transfer from wild-type mice when anti-IL-17A antibody was administered (31.7%). Additionally, Il6 and Il22 tended to be highly expressed after T cell transfer from Il17a(-/-) mice. In conclusion, ROR gamma t(+) ILCs may have an important role in the pathogenesis of chronic colitis in the absence of IL-17A. Blocking the function of IL-17A may upregulate Il6 and recruit ROR gamma t(+) ILCs in chronic colitis, thereby upregulating IL-22 and worsening the clinical outcomes of patients with Crohn's disease. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.title | Role of innate lymphoid cells in chronic colitis during anti-IL-17A therapy | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, Chan Hyuk | - |
dc.contributor.affiliatedAuthor | Eun, Chang Soo | - |
dc.contributor.affiliatedAuthor | Han, Dong Soo | - |
dc.identifier.doi | 10.1038/s41598-019-57233-w | - |
dc.identifier.scopusid | 2-s2.0-85077941286 | - |
dc.identifier.wosid | 000551441800006 | - |
dc.identifier.bibliographicCitation | SCIENTIFIC REPORTS, v.10, no.1, pp.1 - 11 | - |
dc.relation.isPartOf | SCIENTIFIC REPORTS | - |
dc.citation.title | SCIENTIFIC REPORTS | - |
dc.citation.volume | 10 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 11 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | SUPPRESSOR-CELLS | - |
dc.subject.keywordPlus | PLAQUE PSORIASIS | - |
dc.subject.keywordPlus | CROHNS-DISEASE | - |
dc.subject.keywordPlus | DOUBLE-BLIND | - |
dc.subject.keywordPlus | TH17 CELLS | - |
dc.subject.keywordPlus | T-CELLS | - |
dc.subject.keywordPlus | SECUKINUMAB | - |
dc.subject.keywordPlus | INTERLEUKIN-17 | - |
dc.subject.keywordPlus | MODERATE | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.identifier.url | https://www.nature.com/articles/s41598-019-57233-w | - |
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