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Atherogenic index of plasma and the risk of rapid progression of coronary atherosclerosis beyond traditional risk factors

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dc.contributor.authorWon, Ki-Bum-
dc.contributor.authorHeo, Ran-
dc.contributor.authorPark, Hyung-Bok-
dc.contributor.authorLee, Byoung Kwon-
dc.contributor.authorLin, Fay Y.-
dc.contributor.authorHadamitzky, Martin-
dc.contributor.authorKim, Yong-Jin-
dc.contributor.authorSung, Ji Min-
dc.contributor.authorConte, Edoardo-
dc.contributor.authorAndreini, Daniele-
dc.contributor.authorPontone, Gianluca-
dc.contributor.authorBudoff, Matthew J.-
dc.contributor.authorGottlieb, Ilan-
dc.contributor.authorChun, Eun Ju-
dc.contributor.authorCademartiri, Filippo-
dc.contributor.authorMaffei, Erica-
dc.contributor.authorMarques, Hugo-
dc.contributor.authorGoncalves, Pedro de Araujo-
dc.contributor.authorLeipsic, Jonathon A.-
dc.contributor.authorLee, Sang-Eun-
dc.contributor.authorShin, Sanghoon-
dc.contributor.authorChoi, Jung Hyun-
dc.contributor.authorVirmani, Renu-
dc.contributor.authorSamady, Habib-
dc.contributor.authorChinnaiyan, Kavitha-
dc.contributor.authorBerman, Daniel S.-
dc.contributor.authorNarula, Jagat-
dc.contributor.authorShaw, Leslee J.-
dc.contributor.authorBax, Jeroen J.-
dc.contributor.authorMin, James K.-
dc.contributor.authorChang, Hyuk-Jae-
dc.date.accessioned2021-07-30T04:44:47Z-
dc.date.available2021-07-30T04:44:47Z-
dc.date.created2021-07-14-
dc.date.issued2021-05-
dc.identifier.issn0021-9150-
dc.identifier.urihttps://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/1159-
dc.description.abstractBackground and aims: The atherogenic index of plasma (AIP) has been suggested as a marker of plasma athe-rogenicity. This study aimed to assess the association between AIP and the rapid progression of coronary atherosclerosis using serial coronary computed tomography angiography (CCTA). Methods: A total of 1488 adults (60.9 +/- 9.2 years, 58.9% male) who underwent serial CCTA with a median inter-scan period of 3.4 years were included. AIP was defined as the base 10 logarithm of the ratio of the concen-trations of triglyceride to high-density lipoprotein cholesterol. Rapid plaque progression (RPP) was defined as the change of percentage atheroma volume (PAV) >1.0%/year. All participants were divided into three groups based on AIP tertiles. Results: Baseline total PAV (median [interquartile range (IQR)]) (%) (group I [lowest]: 1.91 [0.00, 6.21] vs. group II: 2.82 [0.27, 8.83] vs. group III [highest]: 2.70 [0.41, 7.50]), the annual change of total PAV (median [IQR]) (%/year) (group I: 0.27 [0.00, 0.81] vs. group II: 0.37 [0.04, 1.11] vs. group III: 0.45 [0.06, 1.25]), and the incidence of RPP (group I: 19.7% vs. group II: 27.3% vs. group III: 31.4%) were significantly different among AIP tertiles (all p < 0.05). In multiple logistic regression analysis, the risk of RPP was increased in group III (odds ratio: 1.52, 95% confidence interval: 1.02 & ndash;2.26; p = 0.042) compared to group I after adjusting for clinical factors and baseline total PAV. Conclusions: Based on serial CCTA findings, AIP is an independent predictive marker for RPP beyond traditional risk factors.-
dc.language영어-
dc.language.isoen-
dc.publisherELSEVIER IRELAND LTD-
dc.titleAtherogenic index of plasma and the risk of rapid progression of coronary atherosclerosis beyond traditional risk factors-
dc.typeArticle-
dc.contributor.affiliatedAuthorHeo, Ran-
dc.identifier.doi10.1016/j.atherosclerosis.2021.03.009-
dc.identifier.scopusid2-s2.0-85103571358-
dc.identifier.wosid000645464100006-
dc.identifier.bibliographicCitationATHEROSCLEROSIS, v.324, pp.46 - 51-
dc.relation.isPartOfATHEROSCLEROSIS-
dc.citation.titleATHEROSCLEROSIS-
dc.citation.volume324-
dc.citation.startPage46-
dc.citation.endPage51-
dc.type.rimsART-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaCardiovascular System & Cardiology-
dc.relation.journalWebOfScienceCategoryCardiac & Cardiovascular Systems-
dc.relation.journalWebOfScienceCategoryPeripheral Vascular Disease-
dc.subject.keywordPlusCOMPUTED TOMOGRAPHIC ANGIOGRAPHY-
dc.subject.keywordPlusDENSITY-LIPOPROTEIN CHOLESTEROL-
dc.subject.keywordPlusSCCT GUIDELINES-
dc.subject.keywordPlusPLAQUE BURDEN-
dc.subject.keywordPlusTG/HDL-C-
dc.subject.keywordPlusDISEASE-
dc.subject.keywordPlusIMPACT-
dc.subject.keywordPlusVOLUME-
dc.subject.keywordPlusCOMMITTEE-
dc.subject.keywordPlusOUTCOMES-
dc.subject.keywordAuthorAtherogenic index of plasma-
dc.subject.keywordAuthorAtherosclerosis-
dc.subject.keywordAuthorCoronary artery disease-
dc.subject.keywordAuthorCoronary computed tomography angiography-
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0021915021001179?via%3Dihub-
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