PARaDIM: A PHITS-Based Monte Carlo Tool for Internal Dosimetry with Tetrahedral Mesh Computational Phantoms
DC Field | Value | Language |
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dc.contributor.author | Carter, Lukas M. | - |
dc.contributor.author | Crawford, Troy M. | - |
dc.contributor.author | Sato, Tatsuhiko | - |
dc.contributor.author | Furuta, Takuya | - |
dc.contributor.author | Choi, Chansoo | - |
dc.contributor.author | Kim, Chan Hyeong | - |
dc.contributor.author | Brown, Justin L. | - |
dc.contributor.author | Bolch, Wesley E. | - |
dc.contributor.author | Zanzonico, Pat B. | - |
dc.contributor.author | Lewis, Jason S. | - |
dc.date.accessioned | 2021-08-02T10:28:00Z | - |
dc.date.available | 2021-08-02T10:28:00Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2019-12 | - |
dc.identifier.issn | 0161-5505 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/11607 | - |
dc.description.abstract | Mesh-type and voxel-based computational phantoms comprise the current state of the art for internal dose assessment via Monte Carlo simulations but excel in different aspects, with mesh-type phantoms offering advantages over their voxel counterparts in terms of their flexibility and realistic representation of detailed patient- or subject-specific anatomy. We have developed PARaDIM (pronounced "paradigm": Particle and Heavy Ion Transport Code System-Based Application for Radionuclide Dosimetry in Meshes), a freeware application for implementing tetrahedral mesh-type phantoms in absorbed dose calculations. It considers all medically relevant radionuclides, including alpha, beta, gamma, positron, and Auger/conversion electron emitters, and handles calculation of mean dose to individual regions, as well as 3-dimensional dose distributions for visualization and analysis in a variety of medical imaging software. This work describes the development of PARaDIM, documents the measures taken to test and validate its performance, and presents examples of its uses. Methods: Human, small-animal, and cell-level dose calculations were performed with PARaDIM and the results compared with those of widely accepted dosimetry programs and literature data. Several tetrahedral phantoms were developed or adapted using computer-aided modeling techniques for these comparisons. Results: For human dose calculations, agreement of PARaDIM with OLINDA 2.0 was good-within 10%-20% for most organs-despite geometric differences among the phantoms tested. Agreement with MIRDcell for cell-level S value calculations was within 5% in most cases. Conclusion: PARaDIM extends the use of Monte Carlo dose calculations to the broader community in nuclear medicine by providing a user-friendly graphical user interface for calculation setup and execution. PARaDIM lever-ages the enhanced anatomic realism provided by advanced computational reference phantoms or bespoke image-derived phantoms to enable improved assessments of radiation doses in a variety of radiopharmaceutical use cases, research, and preclinical development. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | SOC NUCLEAR MEDICINE INC | - |
dc.title | PARaDIM: A PHITS-Based Monte Carlo Tool for Internal Dosimetry with Tetrahedral Mesh Computational Phantoms | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Chan Hyeong | - |
dc.identifier.doi | 10.2967/jnumed.119.229013 | - |
dc.identifier.scopusid | 2-s2.0-85075962208 | - |
dc.identifier.wosid | 000500568800026 | - |
dc.identifier.bibliographicCitation | JOURNAL OF NUCLEAR MEDICINE, v.60, no.12, pp.1802 - 1811 | - |
dc.relation.isPartOf | JOURNAL OF NUCLEAR MEDICINE | - |
dc.citation.title | JOURNAL OF NUCLEAR MEDICINE | - |
dc.citation.volume | 60 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 1802 | - |
dc.citation.endPage | 1811 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.relation.journalWebOfScienceCategory | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.subject.keywordPlus | MONOENERGETIC ELECTRON | - |
dc.subject.keywordPlus | S-VALUES | - |
dc.subject.keywordPlus | PARTICLE | - |
dc.subject.keywordPlus | RADIATION | - |
dc.subject.keywordPlus | SOFTWARE | - |
dc.subject.keywordPlus | VERSION | - |
dc.subject.keywordAuthor | PARaDIM | - |
dc.subject.keywordAuthor | PHITS | - |
dc.subject.keywordAuthor | dosimetry | - |
dc.subject.keywordAuthor | tetrahedral mesh | - |
dc.subject.keywordAuthor | phantom | - |
dc.identifier.url | https://jnm.snmjournals.org/content/60/12/1802 | - |
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