HERES, a lncRNA that regulates canonical and noncanonical Wnt signaling pathways via interaction with EZH2
DC Field | Value | Language |
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dc.contributor.author | You, Bo-Hyun | - |
dc.contributor.author | Yoon, Jung-Ho | - |
dc.contributor.author | Kang, Hoin | - |
dc.contributor.author | Lee, Eun Kyung | - |
dc.contributor.author | Lee, Sang Kil | - |
dc.contributor.author | Nam, Jin-Wu | - |
dc.date.accessioned | 2021-08-02T10:28:17Z | - |
dc.date.available | 2021-08-02T10:28:17Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2019-12 | - |
dc.identifier.issn | 0027-8424 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/11633 | - |
dc.description.abstract | Wnt signaling through both canonical and noncanonical pathways plays a core role in development. Dysregulation of these pathways often causes cancer development and progression. Although the pathways independently contribute to the core processes, a regulatory molecule that commonly activates both of them has not yet been reported. Here, we describe a long noncoding RNA (lncRNA), HERES, that epigenetically regulates both canonical and noncanonical Wnt signaling pathways in esophageal squamous cell carcinoma (ESCC). For this study, we performed RNA-seq analysis on Korean ESCC patients and validated these results on a larger ESCC cohort to identify lncRNAs commonly dysregulated in ESCCs. Six of the dysregulated lncRNAs were significantly associated with the clinical outcomes of ESCC patients and defined 4 ESCC subclasses with different prognoses. HERES reduction repressed cell proliferation, migration, invasion, and colony formation in ESCC cell lines and tumor growth in xenograft models. HERES appears to be a transacting factor that regulates CACNA2D3, SFRP2, and CXXC4 simultaneously to activate Wnt signaling pathways through an interaction with EZH2 via its G-quadruple structure-like motif. Our results suggest. that HERES holds substantial potential as a therapeutic target for ESCC and probably other cancers caused by defects in Wnt signaling pathways. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | NATL ACAD SCIENCES | - |
dc.title | HERES, a lncRNA that regulates canonical and noncanonical Wnt signaling pathways via interaction with EZH2 | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Nam, Jin-Wu | - |
dc.identifier.doi | 10.1073/pnas.1912126116 | - |
dc.identifier.scopusid | 2-s2.0-85076195379 | - |
dc.identifier.wosid | 000500804600040 | - |
dc.identifier.bibliographicCitation | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v.116, no.49, pp.24620 - 24629 | - |
dc.relation.isPartOf | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | - |
dc.citation.title | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | - |
dc.citation.volume | 116 | - |
dc.citation.number | 49 | - |
dc.citation.startPage | 24620 | - |
dc.citation.endPage | 24629 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | LONG NONCODING RNAS | - |
dc.subject.keywordPlus | ESOPHAGEAL CANCER | - |
dc.subject.keywordPlus | METHYLATION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | PROMOTES | - |
dc.subject.keywordPlus | CATENIN | - |
dc.subject.keywordPlus | EVOLUTION | - |
dc.subject.keywordPlus | CACNA2D3 | - |
dc.subject.keywordPlus | REPEATS | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordAuthor | epigenetic regulation | - |
dc.subject.keywordAuthor | long noncoding RNA | - |
dc.subject.keywordAuthor | Wnt signaling pathway | - |
dc.subject.keywordAuthor | esophageal squamous cell carcinoma | - |
dc.identifier.url | https://www.pnas.org/doi/full/10.1073/pnas.1912126116 | - |
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