The clinical behavior and survival of patients with hepatocellular carcinoma and a family history of the disease
DC Field | Value | Language |
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dc.contributor.author | An, Jihyun | - |
dc.contributor.author | Chang, Seheon | - |
dc.contributor.author | Kim, Ha Il | - |
dc.contributor.author | Song, Gi-Won | - |
dc.contributor.author | Shim, Ju Hyun | - |
dc.date.accessioned | 2021-08-02T10:29:01Z | - |
dc.date.available | 2021-08-02T10:29:01Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2019-11 | - |
dc.identifier.issn | 2045-7634 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/11706 | - |
dc.description.abstract | Purpose Familial clustering is a common feature of hepatocellular carcinoma (HCC) as well as a risk factor for the disease. We aimed to assess whether such a family history affected prognostic outcomes in patients with HCC diagnosed at different stages of the disease. Materials/Methods This hospital registry-based cohort study included 5484 patients initially diagnosed with HCC. Individual family histories of cancer were obtained by interview and reported by trained nurses who constructed three-generation pedigrees. Overall survival data were compared between cases with and without first-degree relatives affected by HCC, with adjustment for other potential predictors. Results Of 5484 patients, 845 (15.4%) had first-degree relatives with a history of HCC. Family history was associated with longer survival in the entire cohort (adjusted hazard ratio [HR] 0.89, 95% confidence interval [CI] 0.80-0.98, P = .025). A significant trend for reduced risk of death with increasing number of affected family members was also observed (P for trend = 0.018). The stage-stratified analysis showed that the presence of family history was especially associated with a reduced risk of death in the subset of patients with HCC at a (very) early stage (adjusted HR 0.83, 95% CI 0.69-0.99; P = .042). The proportion of cases receiving curative treatment was also higher in early-stage patients with a family history (72.6% vs 63.3%; P < .001). Conclusions A first-degree family history of the disease is a prognostic factor for improved survival in patients with HCC, especially in those whose tumors can be cured by radical treatments. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.title | The clinical behavior and survival of patients with hepatocellular carcinoma and a family history of the disease | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | An, Jihyun | - |
dc.identifier.doi | 10.1002/cam4.2543 | - |
dc.identifier.scopusid | 2-s2.0-85073996119 | - |
dc.identifier.wosid | 000486819100001 | - |
dc.identifier.bibliographicCitation | CANCER MEDICINE, v.8, no.15, pp.6624 - 6633 | - |
dc.relation.isPartOf | CANCER MEDICINE | - |
dc.citation.title | CANCER MEDICINE | - |
dc.citation.volume | 8 | - |
dc.citation.number | 15 | - |
dc.citation.startPage | 6624 | - |
dc.citation.endPage | 6633 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.subject.keywordPlus | BREAST-CANCER | - |
dc.subject.keywordPlus | PROSTATE-CANCER | - |
dc.subject.keywordPlus | LIVER-CANCER | - |
dc.subject.keywordPlus | HEPATITIS-B | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordPlus | IMPACT | - |
dc.subject.keywordPlus | RECURRENCE | - |
dc.subject.keywordPlus | AMERICAN | - |
dc.subject.keywordPlus | WOMEN | - |
dc.subject.keywordAuthor | clustering | - |
dc.subject.keywordAuthor | family | - |
dc.subject.keywordAuthor | liver cancer | - |
dc.subject.keywordAuthor | prognosis | - |
dc.subject.keywordAuthor | treatment | - |
dc.identifier.url | https://onlinelibrary.wiley.com/doi/10.1002/cam4.2543 | - |
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