Oral Delivery of Parathyroid Hormone Using a Triple-Padlock Nanocarrier for Osteoporosis via an Enterohepatic Circulation Pathway
DC Field | Value | Language |
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dc.contributor.author | An, Jeong Man | - |
dc.contributor.author | Shahriar, S. M. Shatil | - |
dc.contributor.author | Hwang, Yong Hwa | - |
dc.contributor.author | Hwang, Seung Rim | - |
dc.contributor.author | Lee, Dong Yun | - |
dc.contributor.author | Cho, Sungpil | - |
dc.contributor.author | Lee, Yong-kyu | - |
dc.date.accessioned | 2021-07-30T04:44:53Z | - |
dc.date.available | 2021-07-30T04:44:53Z | - |
dc.date.created | 2021-07-14 | - |
dc.date.issued | 2021-05 | - |
dc.identifier.issn | 1944-8244 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/1184 | - |
dc.description.abstract | Intermittent subcutaneous (S.C.) injection of teriparatide [PTH (1-34)] is one of the effective therapies to cure osteoporosis. However, a long-term repeated administration of teriparatide by S.C. to the patients is highly challenging. Herein, a triple padlock nanocarrier prepared by a taurocholic acid-conjugated chondroitin sulfate A (TCSA) is designed to develop an oral dosage form of recombinant human teriparatide (rhPTH). Oral administration of TCSA/rhPTH to the bilateral ovariectomized (OVX) rats resulted in the recovery of the bone marrow density and healthy serum bone parameters from the severe osteoporotic conditions. Also, it enhanced new bone formation in the osteoporotic tibias. This triple padlock oral delivery platform overcame the current barriers associated with teriparatide administration and exhibited a promising therapeutic effect against osteoporosis. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.title | Oral Delivery of Parathyroid Hormone Using a Triple-Padlock Nanocarrier for Osteoporosis via an Enterohepatic Circulation Pathway | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Dong Yun | - |
dc.identifier.doi | 10.1021/acsami.0c22170 | - |
dc.identifier.scopusid | 2-s2.0-85101576921 | - |
dc.identifier.wosid | 000657202500002 | - |
dc.identifier.bibliographicCitation | ACS APPLIED MATERIALS & INTERFACES, v.13, no.20, pp.23314 - 23327 | - |
dc.relation.isPartOf | ACS APPLIED MATERIALS & INTERFACES | - |
dc.citation.title | ACS APPLIED MATERIALS & INTERFACES | - |
dc.citation.volume | 13 | - |
dc.citation.number | 20 | - |
dc.citation.startPage | 23314 | - |
dc.citation.endPage | 23327 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Multidisciplinary | - |
dc.subject.keywordPlus | OSTEOBLAST DIFFERENTIATION | - |
dc.subject.keywordPlus | CHONDROITIN SULFATE | - |
dc.subject.keywordPlus | BILE-ACID | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | BONE | - |
dc.subject.keywordPlus | MAPK | - |
dc.subject.keywordAuthor | oral delivery | - |
dc.subject.keywordAuthor | osteoporosis | - |
dc.subject.keywordAuthor | parathyroid hormone | - |
dc.subject.keywordAuthor | nanoparticle | - |
dc.subject.keywordAuthor | enterohepatic recycling pathway | - |
dc.identifier.url | https://pubs.acs.org/doi/10.1021/acsami.0c22170 | - |
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