Associations between paraoxonase-1 and systemic lupus erythematosus
DC Field | Value | Language |
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dc.contributor.author | Bae, Sang-Cheol | - |
dc.contributor.author | Lee, Young Ho | - |
dc.date.accessioned | 2021-08-02T10:50:52Z | - |
dc.date.available | 2021-08-02T10:50:52Z | - |
dc.date.issued | 2019-11 | - |
dc.identifier.issn | 0961-2033 | - |
dc.identifier.issn | 1477-0962 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/12309 | - |
dc.description.abstract | Objective The objective of this analysis was to explore associations between paraoxonase-1 levels, gene polymorphisms and systemic lupus erythematosus. Methods Meta-analyses of paraoxonase-1 levels and Q192R and L55M and polymorphisms in systemic lupus erythematosus were conducted. Results Nine articles were incorporated in our meta-analysis, which uncovered that the paraoxonase-1 level was decreased in systemic lupus erythematosus compared to control (standard mean difference = −1.626, 95% confidence interval = −2.829–−0.424, p = 0.008). Ethnicity-specific meta-analysis demonstrated a relation tendency between decreased paraoxonase-1 activity and lupus in Europeans (standard mean difference = −1.236, 95% confidence interval = −2.634–0.163, p = 0.083). Paraoxonase-1 activity was reduced in systemic lupus erythematosus in a single Arab and African population. Decreased paraoxonase-1 activity was found in a small sample of systemic lupus erythematosus patients (standard mean difference = −1.642, 95% confidence interval = −3.076–−0.247, p = 0.021). Ethnicity-specific analysis indicated a relationship between the paraoxonase-1 55 M allele in the Arab systemic lupus erythematosus population. However, a lack of association with systemic lupus erythematosus and the paraoxonase-1 192 R allele was observed. Conclusions Meta-analyses revealed reduced paraoxonase-1 activity in patients with systemic lupus erythematosus and found possible associations between systemic lupus erythematosus and paraoxonase-1 L55M polymorphism in a specific ethnic group. | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | SAGE PUBLICATIONS LTD | - |
dc.title | Associations between paraoxonase-1 and systemic lupus erythematosus | - |
dc.type | Article | - |
dc.publisher.location | 영국 | - |
dc.identifier.doi | 10.1177/0961203319884653 | - |
dc.identifier.scopusid | 2-s2.0-85074497546 | - |
dc.identifier.wosid | 000492667100001 | - |
dc.identifier.bibliographicCitation | LUPUS, v.28, no.13, pp 1571 - 1576 | - |
dc.citation.title | LUPUS | - |
dc.citation.volume | 28 | - |
dc.citation.number | 13 | - |
dc.citation.startPage | 1571 | - |
dc.citation.endPage | 1576 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Rheumatology | - |
dc.relation.journalWebOfScienceCategory | Rheumatology | - |
dc.subject.keywordPlus | PLASMINOGEN-ACTIVATOR INHIBITOR-1 | - |
dc.subject.keywordPlus | RHEUMATOID-ARTHRITIS | - |
dc.subject.keywordPlus | SYNOVIAL-FLUID | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | ATHEROSCLEROSIS | - |
dc.subject.keywordPlus | FIBRINOLYSIS | - |
dc.subject.keywordPlus | DIFFERENCE | - |
dc.subject.keywordPlus | RADICALS | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordAuthor | PON1 | - |
dc.subject.keywordAuthor | polymorphism | - |
dc.subject.keywordAuthor | systemic lupus erythematosus | - |
dc.identifier.url | https://journals.sagepub.com/doi/10.1177/0961203319884653 | - |
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