Comprehensive genome and transcriptome analyses reveal genetic relationship, selection signature, and transcriptome landscape of small-sized Korean native Jeju horse
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Srikanth, Krishnamoorthy | - |
dc.contributor.author | Kim, Nam-Young | - |
dc.contributor.author | Park, WonCheoul | - |
dc.contributor.author | Kim, Jae-Min | - |
dc.contributor.author | Kim, Kwon-Do | - |
dc.contributor.author | Lee, Kyung-Tai | - |
dc.contributor.author | Son, Ju-Hwan | - |
dc.contributor.author | Chai, Han-Ha | - |
dc.contributor.author | Choi, Jung-Woo | - |
dc.contributor.author | Jang, Gul-Won | - |
dc.contributor.author | Kim, Heebal | - |
dc.contributor.author | Ryu, Youn-Chul | - |
dc.contributor.author | Nam, Jin-Wu | - |
dc.contributor.author | Park, Jong-Eun | - |
dc.contributor.author | Kim, Jun-Mo | - |
dc.contributor.author | Lim, Dajeong | - |
dc.date.accessioned | 2021-08-02T10:51:25Z | - |
dc.date.available | 2021-08-02T10:51:25Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2019-11 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/12354 | - |
dc.description.abstract | The Jeju horse, indigenous to the Jeju Island in Korea may have originated from Mongolian horses. Adaptations to the local harsh environment have conferred Jeju horse with unique traits such as small-sized body, stocky head, and shorter limbs. These characteristics have not been studied previously at the genomic level. Therefore, we sequenced and compared the genome of 41 horses belonging to 6 breeds. We identified numerous breed-specific non-synonymous SNPs and loss-of-function mutants. Demographic and admixture analyses showed that, though Jeju horse is genetically the closest to the Mongolian breeds, its genetic ancestry is independent of that of the Mongolian breeds. Genome wide selection signature analysis revealed that genes such as LCORL, MSTN, HMGA2, ZFAT, LASP1, PDK4, and ACTN2, were positively selected in the Jeju horse. RNAseq analysis showed that several of these genes were also differentially expressed in Jeju horse compared to Thoroughbred horse. Comparative muscle fiber analysis showed that, the type I muscle fibre content was substantially higher in Jeju horse compared to Thoroughbred horse. Our results provide insights about the selection of complex phenotypic traits in the small-sized Jeju horse and the novel SNPs identified will aid in designing high-density SNP chip for studying other native horse breeds. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.title | Comprehensive genome and transcriptome analyses reveal genetic relationship, selection signature, and transcriptome landscape of small-sized Korean native Jeju horse | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Nam, Jin-Wu | - |
dc.identifier.doi | 10.1038/s41598-019-53102-8 | - |
dc.identifier.scopusid | 2-s2.0-85074958549 | - |
dc.identifier.wosid | 000496129600021 | - |
dc.identifier.bibliographicCitation | SCIENTIFIC REPORTS, v.9, no.1, pp.1 - 16 | - |
dc.relation.isPartOf | SCIENTIFIC REPORTS | - |
dc.citation.title | SCIENTIFIC REPORTS | - |
dc.citation.volume | 9 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 16 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | EQUINE ACTN3 GENE | - |
dc.subject.keywordPlus | SKELETAL-MUSCLE | - |
dc.subject.keywordPlus | RESEQUENCING REVEALS | - |
dc.subject.keywordPlus | POSITIVE SELECTION | - |
dc.subject.keywordPlus | SEQUENCE-ANALYSIS | - |
dc.subject.keywordPlus | CHEJU HORSES | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordPlus | VARIANTS | - |
dc.subject.keywordPlus | EXERCISE | - |
dc.subject.keywordPlus | POLYMORPHISMS | - |
dc.identifier.url | https://www.nature.com/articles/s41598-019-53102-8 | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
222, Wangsimni-ro, Seongdong-gu, Seoul, 04763, Korea+82-2-2220-1365
COPYRIGHT © 2021 HANYANG UNIVERSITY.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.