바이오분야 분리용 막크로마토그래피 설계 방안How to Design Membrane Chromatography for Bioseparations: A Short Review
- Other Titles
- How to Design Membrane Chromatography for Bioseparations: A Short Review
- Authors
- 박인호; 유승연; 박호범
- Issue Date
- Apr-2021
- Publisher
- 한국막학회
- Keywords
- membrane chromatography; affinity interaction; ion exchange interaction; hydrophobic interaction
- Citation
- 멤브레인, v.31, no.2, pp 145 - 152
- Pages
- 8
- Indexed
- KCI
- Journal Title
- 멤브레인
- Volume
- 31
- Number
- 2
- Start Page
- 145
- End Page
- 152
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/1235
- DOI
- 10.14579/MEMBRANE_JOURNAL.2021.31.2.145
- ISSN
- 1226-0088
- Abstract
- While there are increasing demands on biomolecules separation, resin chromatography lacks in terms of throughput and membrane chromatography is an alternative with high binding capacity and enhanced mass transfer properties. Unlike typical membrane processing, where the performance can only be empirically assessed, understanding how mechanisms work in membrane chromatography is decisive to design biospecific processing. This short review covers three separation mechanisms, including affinity interaction modes for selectively capturing bulk molecules using biospecific sites, ion exchange modes for binding biomolecules using net charges and hydrophobic interaction modes for binding targeted, hydrophobic species. The parameters in designing membrane chromatography that should be considered operation-wise or material-wise, are also further detailed in this paper.
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