Effect of tumor necrosis factor inhibition on spinal inflammation and spinal ankylosis in SKG miceopen access
- Authors
- Lim, Doo-Ho; Lee, Eun-Ju; Kwon, Oh Chan; Hong, Seokchan; Lee, Chang-Keun; Yoo, Bin; Youn, Jeehee; Kim, Tae-Hwan; Kim, Yong-Gil
- Issue Date
- Nov-2019
- Publisher
- NATURE PUBLISHING GROUP
- Citation
- SCIENTIFIC REPORTS, v.9, no.1
- Indexed
- SCI
SCIE
SCOPUS
- Journal Title
- SCIENTIFIC REPORTS
- Volume
- 9
- Number
- 1
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/12367
- DOI
- 10.1038/s41598-019-54549-5
- ISSN
- 2045-2322
2045-2322
- Abstract
- To prevent spinal progression in ankylosing spondylitis, initiating TNF-inhibitor treatment as early as possible is suggested. However, the outcomes are inconsistent in previous clinical studies. Here, we investigated the effect of TNF inhibition alone on spinal progression when used during arthritis development in a murine model. We injected 8-week-old SKG mice with curdlan (curdlan group). We injected adalimumab at 3 and 9 weeks after the first curdlan injection (ADA group). The clinical scores of peripheral arthritis decreased in the ADA group at 3 weeks after first adalimumab injection. Using positron emission tomography-magnetic resonance imaging and histologic examination, spinal inflammation was observed in the curdlan group, and was significantly deceased in the ADA group. However, spinal osteoblast activities by imaging using OsteoSense 680 EX and bone metabolism-related cytokines such as receptor activator of nuclear factor-kappa B ligand, osteoprotegerin, Dickkopf-1, and sclerostin levels except IL-17A level were not different between the two groups. We conclude that treating TNF inhibitor alone reduced peripheral arthritis score and spinal inflammation in curdlan-injected SKG mice but did not decrease the spinal osteoblast activity, suggesting little effect on spinal ankylosis.
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Collections - 서울 의과대학 > 서울 내과학교실 > 1. Journal Articles
- 서울 의과대학 > 서울 해부·세포생물학교실 > 1. Journal Articles
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