Up-regulation of syndecan-2 in proximal colon correlates with acute inflammation
DC Field | Value | Language |
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dc.contributor.author | Hong, Heejeong | - |
dc.contributor.author | Song, Hyun-Kuk | - |
dc.contributor.author | Hwang, Eun Sook | - |
dc.contributor.author | Lee, A. Reum | - |
dc.contributor.author | Han, Dong Soo | - |
dc.contributor.author | Kim, Seong-Eun | - |
dc.contributor.author | Oh, Eok-Soo | - |
dc.date.accessioned | 2021-08-02T10:53:04Z | - |
dc.date.available | 2021-08-02T10:53:04Z | - |
dc.date.created | 2021-05-11 | - |
dc.date.issued | 2019-10 | - |
dc.identifier.issn | 0892-6638 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/12509 | - |
dc.description.abstract | We previously reported that syndecan-2 expression is increased on the colonic epithelium during chronic inflammation. Here, we report that syndecan-2 exhibits a different pattern of site-specific colonic expression during acute inflammation. Syndecan-2 expression was up-regulated predominantly in the proximal colon of dextran sulfate sodium-induced colitis mice. The colitis-associated up-regulation of syndecan-2 was barely detected in Rag-1(-/-) (recombination activating gene 1 knockout) mice under colitis-inducing conditions. Increased syndecan-2 expression correlated with increased levels of infiltrated CD4⁺ IL-17A⁺ T cells in the proximal colon. Serum levels of IL-17A were increased during the acute inflammatory response in normal mice but not Rag-1(-/-) mice. IL-17A directly induced IL-17 receptor (IL-17RA) and syndecan-2 expression in ex vivo-cultured proximal colon tissues and adenoma cell lines from proximal colon. IL-17RA knockdown reduced the IL-17A-mediated syndecan-2 expression in SNU1235 cells. No elevation of syndecan-2 or IL-17RA was observed in colonic tissues from IL-17A(-/-) mice during colitis induction. Finally, increased expression of syndecan-2 and IL-17RA was observed in the proximal colons of cecal ligation and puncture-induced sepsis mice and infectious pan colitis patients. Together, these data suggest that acute inflammation induces syndecan-2 expression predominantly in the proximal colon via IL-17A-IL-17RA signaling during the early stage of the inflammatory response and that proximal colonic syndecan-2 might be a biomarker for acute inflammation.-Hong, H., Song, H.-K., Hwang, E. S., Lee, A. R., Han, D. S., Kim, S.-E., Oh, E.-S. Up-regulation of syndecan-2 in proximal colon correlates with acute inflammation. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | FEDERATION AMER SOC EXP BIOL | - |
dc.title | Up-regulation of syndecan-2 in proximal colon correlates with acute inflammation | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Han, Dong Soo | - |
dc.identifier.doi | 10.1096/fj.201900561R | - |
dc.identifier.scopusid | 2-s2.0-85072717162 | - |
dc.identifier.wosid | 000489166300065 | - |
dc.identifier.bibliographicCitation | FASEB JOURNAL, v.33, no.10, pp.11381 - 11395 | - |
dc.relation.isPartOf | FASEB JOURNAL | - |
dc.citation.title | FASEB JOURNAL | - |
dc.citation.volume | 33 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 11381 | - |
dc.citation.endPage | 11395 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Life Sciences & Biomedicine - Other Topics | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.subject.keywordPlus | BOWEL-DISEASE | - |
dc.subject.keywordPlus | T-CELLS | - |
dc.subject.keywordPlus | COLITIS | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | LYMPHOCYTES | - |
dc.subject.keywordPlus | ADHESION | - |
dc.subject.keywordPlus | MODELS | - |
dc.subject.keywordAuthor | colitis | - |
dc.subject.keywordAuthor | IL17RA | - |
dc.subject.keywordAuthor | proteoglycan | - |
dc.identifier.url | https://faseb.onlinelibrary.wiley.com/doi/full/10.1096/fj.201900561R | - |
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