Cough-Related Laryngeal Sensations and Triggers in Adults With Chronic Cough: Symptom Profile and Impactopen access
- Authors
- Won, Ha-Kyeong; Kang, Sung-Yoon; Kang, Yewon; An, Jin; Lee, Ji-Hyang; Lee, Sang Min; Kwon, Jae-Woo; Kim, Min-Hye; Jo, Eun-Jung; Lee, Seung-Eun; Kim, Sae-Noon; Kim, Sang-Heon; Chang, Yoon-Seok; Kim, Sang-Hoon; Lee, Byung-Jae; Cho, Sang-Neon; Birring, Surinder S.; Song, Woo-Jung
- Issue Date
- Sep-2019
- Publisher
- KOREAN ACAD ASTHMA ALLERGY & CLINICAL IMMUNOLOGY
- Keywords
- Cough; hypersensitivity; symptom assessment
- Citation
- ALLERGY ASTHMA & IMMUNOLOGY RESEARCH, v.11, no.5, pp.622 - 631
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- ALLERGY ASTHMA & IMMUNOLOGY RESEARCH
- Volume
- 11
- Number
- 5
- Start Page
- 622
- End Page
- 631
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/12557
- DOI
- 10.4168/aair.2019.11.5.622
- ISSN
- 2092-7355
- Abstract
- Purpose: Recent evidence suggests that cough hypersensitivity may be a common feature of chronic cough in adults. However, the clinical relevance remains unclear. This study evaluated the cough-related symptom profile and the clinical relevance and impact of cough hypersensitivity in adults with chronic cough.
Methods: This cross-sectional multi-center study compared cough-related laryngeal sensations and cough triggers in patients with unexplained chronic cough following investigations and in unselected patients newly referred for chronic cough. A structured questionnaire was used to assess abnormal laryngeal sensations and cough triggers. Patients with unexplained cough were also evaluated using the Leicester Cough Questionnaire (LCQ) and a cough visual analogue scale (VAS), and these scores were assessed for correlations with the number of triggers and laryngeal sensations.
Results: This study recruited 478 patients, including 62 with unexplained chronic cough and 416 with chronic cough. Most participants reported abnormal laryngeal sensations and cough triggers. Laryngeal sensations (4.4 +/- 1.5 vs. 3.9 +/- 1.9; P= 0.049) and cough triggers (6.9 +/- 2.6 vs. 5.0 +/- 2.8; P< 0.001) were more frequent in patients with unexplained chronic cough than in those with chronic cough. The number of triggers and laryngeal sensations score significantly correlated with LCQ (r= -0.51, P< 0.001) and cough VAS score (r= 0.53, P< 0.001) in patients with unexplained chronic cough.
Conclusions: Cough hypersensitivity may be a common feature in adult patients with chronic cough, especially those with unexplained chronic cough. Cough-related health status and cough severity were inversely associated with the number of triggers and laryngeal sensations, suggesting potential relevance of assessing cough hypersensitivity in chronic cough patients.
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