Preparation and evaluation of a porous molecularly imprinted polymer for selective recognition of the antiepileptic drug carbamazepine
DC Field | Value | Language |
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dc.contributor.author | Mohiuddin, Irshad | - |
dc.contributor.author | Berhanu, Asnake Lealem | - |
dc.contributor.author | Malik, Ashok Kumar | - |
dc.contributor.author | Aulakh, Jatinder Singh | - |
dc.contributor.author | Lee, Jechan | - |
dc.contributor.author | Kim, Ki-Hyun | - |
dc.date.accessioned | 2021-08-02T10:53:46Z | - |
dc.date.available | 2021-08-02T10:53:46Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2019-09 | - |
dc.identifier.issn | 0013-9351 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/12564 | - |
dc.description.abstract | A novel and porous molecularly imprinted polymer (PMIP) was synthesized and used as a solid-phase extraction adsorbent for preconcentration of carbamazepine (CBZ) prior to its quantitation by high-performance liquid chromatography (HPLC) in various sample forms (e.g., drinking water, river water, hospital wastewater, and pharmaceuticals). PMIP-CBZ was applied to a polymerization process in which polystyrene spheres were coated with a silica layer. Removal of polystyrene spheres and formation of porous silica facilitated the recovery of CBZ (99.4%) during the extraction process. Site accessibility to the surface of PMIP-CBZ increased the density of high recognition sites. PMIP-CBZ was characterized by Fourier-transform infrared spectroscopy and scanning electron microscopy. The key variables influencing the extraction efficiency of PMIP (e.g., adsorbent loading, eluent type, eluent volume, reusability of the adsorbent, and cross-reactivity) were optimized. The optimized protocol was successfully employed to quantify CBZ with limit of detection and limit of quantification as 0.082 and 0.270 ng/mL, respectively (linear detection range: 0.5-250 ng/mL and a relative standard deviation: < 5%). Use of the PMIP adsorbent resulted in a sensitive and stable method for efficiently quantitation of CBZ from various real sample matrices. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.title | Preparation and evaluation of a porous molecularly imprinted polymer for selective recognition of the antiepileptic drug carbamazepine | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Ki-Hyun | - |
dc.identifier.doi | 10.1016/j.envres.2019.108580 | - |
dc.identifier.scopusid | 2-s2.0-85071713573 | - |
dc.identifier.wosid | 000483410200008 | - |
dc.identifier.bibliographicCitation | ENVIRONMENTAL RESEARCH, v.176, pp.1 - 9 | - |
dc.relation.isPartOf | ENVIRONMENTAL RESEARCH | - |
dc.citation.title | ENVIRONMENTAL RESEARCH | - |
dc.citation.volume | 176 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 9 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Environmental Sciences & Ecology | - |
dc.relation.journalResearchArea | Public, Environmental & Occupational Health | - |
dc.relation.journalWebOfScienceCategory | Environmental Sciences | - |
dc.relation.journalWebOfScienceCategory | Public, Environmental & Occupational Health | - |
dc.subject.keywordPlus | SOLID-PHASE EXTRACTION | - |
dc.subject.keywordPlus | LIQUID-CHROMATOGRAPHY | - |
dc.subject.keywordPlus | RISK-ASSESSMENT | - |
dc.subject.keywordPlus | PHARMACEUTICALS | - |
dc.subject.keywordPlus | METABOLITES | - |
dc.subject.keywordPlus | REMOVAL | - |
dc.subject.keywordPlus | MICROEXTRACTION | - |
dc.subject.keywordPlus | DICLOFENAC | - |
dc.subject.keywordPlus | SEPARATION | - |
dc.subject.keywordPlus | PLASMA | - |
dc.subject.keywordAuthor | Porous molecularly imprinted polymer | - |
dc.subject.keywordAuthor | Carbamazepine | - |
dc.subject.keywordAuthor | Solid-phase extraction | - |
dc.subject.keywordAuthor | Aqueous samples | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0013935119303779?via%3Dihub | - |
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