Increased mortality in patients with non cystic fibrosis bronchiectasis with respiratory comorbidities
DC Field | Value | Language |
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dc.contributor.author | Choi, Hayoung | - |
dc.contributor.author | Yang, Bumhee | - |
dc.contributor.author | Kim, Yun Jin | - |
dc.contributor.author | Sin, Sooim | - |
dc.contributor.author | Jo, Yong Suk | - |
dc.contributor.author | Kim, Youlim | - |
dc.contributor.author | Park, Hye Yun | - |
dc.contributor.author | Ra, Seung Won | - |
dc.contributor.author | Oh, Yeon-Mok | - |
dc.contributor.author | Chung, Sung Jun | - |
dc.contributor.author | Yeo, Yoomi | - |
dc.contributor.author | Park, Dong Won | - |
dc.contributor.author | Park, Tai Sun | - |
dc.contributor.author | Moon, Ji-Yong | - |
dc.contributor.author | Kim, Sang-Heon | - |
dc.contributor.author | Kim, Tae-Hyung | - |
dc.contributor.author | Yoon, Ho Joo | - |
dc.contributor.author | Sohn, Jang Won | - |
dc.contributor.author | Lee, Hyun | - |
dc.date.accessioned | 2021-07-30T04:48:06Z | - |
dc.date.available | 2021-07-30T04:48:06Z | - |
dc.date.created | 2021-07-14 | - |
dc.date.issued | 2021-03 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/1319 | - |
dc.description.abstract | There are limited data regarding whether mortality is higher in patients with non cystic fibrosis bronchiectasis (bronchiectasis) than in those without bronchiectasis. Using 2005-2015 data from the Korean National Health Insurance Service, we evaluated hazard ratio (HR) for all-cause mortality in the bronchiectasis cohort relative to the matched cohort. The effect of comorbidities over the study period on the relative mortality was also assessed. All-cause mortality was significantly higher in the bronchiectasis cohort than in the matched cohort (2505/100,000 vs 2142/100,000 person-years, respectively; P<0.001). Mortality risk was 1.15-fold greater in the bronchiectasis cohort than in the matched cohort (95% confidence interval [CI] 1.09-1.22); mortality was greatest among elderly patients (HR=1.17, 95% CI 1.10-1.25) and men (HR=1.19, 95% CI 1.10-1.29). Comorbidities over the study period significantly increased the risk of death in the bronchiectasis cohort relative to the matched cohort: asthma (adjusted HR=1.20, 95% CI 1.11-1.30), chronic obstructive pulmonary disease (adjusted HR=1.24, 95% CI 1.15-1.34), pneumonia (adjusted HR=1.50, 95% CI 1.39-1.63), lung cancer (adjusted HR=1.85, 95% CI 1.61-2.12), and cardiovascular disease (adjusted HR=1.34, 95% CI 1.23-1.45). In contrast, there were no significant differences in the risk of death in patients without bronchiectasis-related comorbidities and the matched cohort, except in the case of non-tuberculous mycobacterial infection. In conclusion, all-cause mortality was higher in patients with bronchiectasis cohort than those without bronchiectasis, especially in elderly patients and men. Comorbidities over the study period played a major role in increasing mortality in patients with bronchiectasis relative to those without bronchiectasis. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | NATURE RESEARCH | - |
dc.title | Increased mortality in patients with non cystic fibrosis bronchiectasis with respiratory comorbidities | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, Dong Won | - |
dc.contributor.affiliatedAuthor | Park, Tai Sun | - |
dc.contributor.affiliatedAuthor | Moon, Ji-Yong | - |
dc.contributor.affiliatedAuthor | Kim, Sang-Heon | - |
dc.contributor.affiliatedAuthor | Kim, Tae-Hyung | - |
dc.contributor.affiliatedAuthor | Yoon, Ho Joo | - |
dc.contributor.affiliatedAuthor | Sohn, Jang Won | - |
dc.contributor.affiliatedAuthor | Lee, Hyun | - |
dc.identifier.doi | 10.1038/s41598-021-86407-8 | - |
dc.identifier.scopusid | 2-s2.0-85103558736 | - |
dc.identifier.wosid | 000636358400069 | - |
dc.identifier.bibliographicCitation | SCIENTIFIC REPORTS, v.11, no.1, pp.1 - 9 | - |
dc.relation.isPartOf | SCIENTIFIC REPORTS | - |
dc.citation.title | SCIENTIFIC REPORTS | - |
dc.citation.volume | 11 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 9 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | ECONOMIC BURDEN | - |
dc.subject.keywordPlus | UNITED-STATES | - |
dc.subject.keywordPlus | LUNG-CANCER | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordPlus | PREVALENCE | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | TRENDS | - |
dc.subject.keywordPlus | INDEX | - |
dc.subject.keywordPlus | DEATH | - |
dc.subject.keywordPlus | COPD | - |
dc.identifier.url | https://www.nature.com/articles/s41598-021-86407-8 | - |
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