Adherence to Asacol once daily versus divided regimen for maintenance therapy in ulcerative colitis: a prospective, multicenter, randomized study
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Soo-Kyung | - |
dc.contributor.author | Park, Sang Hyun | - |
dc.contributor.author | Eun, Chang Soo | - |
dc.contributor.author | Seo, Geom Seog | - |
dc.contributor.author | Kim, Jong Pil | - |
dc.contributor.author | Kim, Tae Oh | - |
dc.contributor.author | Park, Dong-Il | - |
dc.date.accessioned | 2021-08-02T11:28:14Z | - |
dc.date.available | 2021-08-02T11:28:14Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2019-07 | - |
dc.identifier.issn | 1598-9100 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/13363 | - |
dc.description.abstract | Background/Aims: A once-daily (OD) regimen of 5-ami nosaticylic acid (5-ASA) was easier to comply with than a divided daily (DD) regimen, and that treatment efficacy for ulcerative colitis (UC) was not affected by the dosing regimen. This study evaluated treatment adherence of OD and DD dosing in the Korean UC patients. Methods: This study was a prospective, multicenter, randomized trial. UC patients were enrolled who have been in remission for more than 3 months. Patients were randomly assigned to the OD or DD group in a 1:1 ratio. The primary endpoint was adherence rate measured by tablet counts and self-reported adherence rate at 3, 6, 9, and 12 months. The relapse rate was measured at 1 year. Results: Data from the 180 patients who were randomized were analyzed. Both self-reported adherence rate and adherence rate measured by tablet counts were not different at every points, including 1 year. The patients satisfaction of the OD group was higher than that of the DD group (P<0.001). At 1 year, 91.2% and 95.5% of patients in the OD group and DD group had maintained clinical remission, respectively (P=0.37). Conclusions: The adherence rates were not different between the OD group and DD group. The patients satisfaction was higher in the OD group than in the DD group. 5-ASA OD dosing might have the same effect as DD for the maintenance of UC remission. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | 대한장연구학회 | - |
dc.title | Adherence to Asacol once daily versus divided regimen for maintenance therapy in ulcerative colitis: a prospective, multicenter, randomized study | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Eun, Chang Soo | - |
dc.identifier.doi | 10.5217/ir.2018.00064 | - |
dc.identifier.scopusid | 2-s2.0-85077991754 | - |
dc.identifier.wosid | 000477572400007 | - |
dc.identifier.bibliographicCitation | Intestinal research, v.17, no.3, pp.349 - 356 | - |
dc.relation.isPartOf | Intestinal research | - |
dc.citation.title | Intestinal research | - |
dc.citation.volume | 17 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 349 | - |
dc.citation.endPage | 356 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002489071 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Gastroenterology & Hepatology | - |
dc.relation.journalWebOfScienceCategory | Gastroenterology & Hepatology | - |
dc.subject.keywordPlus | FECAL CALPROTECTIN | - |
dc.subject.keywordPlus | MAINTAINING REMISSION | - |
dc.subject.keywordPlus | RELEASE MESALAZINE | - |
dc.subject.keywordPlus | ORAL PREPARATION | - |
dc.subject.keywordPlus | CLINICAL-TRIAL | - |
dc.subject.keywordPlus | MESALAMINE | - |
dc.subject.keywordPlus | RELAPSE | - |
dc.subject.keywordPlus | MANAGEMENT | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | 5-ASA | - |
dc.subject.keywordAuthor | Colitis | - |
dc.subject.keywordAuthor | ulcerative | - |
dc.subject.keywordAuthor | Mesalamine | - |
dc.subject.keywordAuthor | inflammatory bowel disease | - |
dc.identifier.url | https://www.irjournal.org/journal/view.php?doi=10.5217/ir.2018.00064 | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
222, Wangsimni-ro, Seongdong-gu, Seoul, 04763, Korea+82-2-2220-1365
COPYRIGHT © 2021 HANYANG UNIVERSITY.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.