Nonsteroidal Anti-inflammatory Drugs-sparing Effect of Symptomatic Slow-acting Drugs for Osteoarthritis in Knee Osteoarthritis Patients
DC Field | Value | Language |
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dc.contributor.author | Cho, Soo-Kyung | - |
dc.contributor.author | Kim, Hyoungyoung | - |
dc.contributor.author | Park, Ha-Rim | - |
dc.contributor.author | Choi, Wooseok | - |
dc.contributor.author | Choi, Seongmi | - |
dc.contributor.author | Jung, Sun-Young | - |
dc.contributor.author | Jang, Eun Jin | - |
dc.contributor.author | Sung, Yoon-Kyoung | - |
dc.date.accessioned | 2021-08-02T11:28:20Z | - |
dc.date.available | 2021-08-02T11:28:20Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2019-07 | - |
dc.identifier.issn | 2093-940X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/13370 | - |
dc.description.abstract | Objective. To evaluate the nonsteroidal anti-inflammatory drugs (NSAID)-sparing effect of symptomatic slow-acting drugs for osteoarthritis (SYSADOA) in knee osteoarthritis (OA) patients. Methods. A retrospective study was conducted on a cohort of knee OA patients who visited a single academic referral hospital from 2013 to 2014. Among all patients, NSAID users in their first visit were extracted and divided into SYSADOA users and SYSADOA non-users. All patients were observed from their first visit with knee OA to their last visit, NSAID discontinuation, or the date of data collection, July 2017 (mean observational periods: 369.1 days). To evaluate the NSAID-sparing effect of SYSADOA, Cox regression analysis was performed after adjusting for confounding factors. Results. Patients for this study (n=212) were divided into SYSADOA users (n=57) and SYSADOA non-users (n=155). The mean age (68.8 vs. 66.6 years old, p=0.31) and the number of comorbidities (p=0.73) were comparable between the two groups. The SYSADOA users showed higher Kellgren-Lawrence (KL) grade (66.7% of patients with more than KL grade 3) than SYSADOA non-users (42.6% of patients with more than KL grade 3) (p=0.02). In treatment, the frequency of intra-articular injection was higher in the SYSADOA user group than the SYSADOA non-user group (33.3% vs. 9.0%, p<0.01). In Cox regression analysis, SYSADOA use contributed to NSAID discontinuation in knee OA patients (hazard ratio 2.97, 95% confidential interval 1.42 similar to 6.22). Conclusion. This real-world analysis demonstrated that SYSADOA use combined with NSAIDs had a significant effect on NSAID discontinuation in patients with knee OA. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | 대한류마티스학회 | - |
dc.title | Nonsteroidal Anti-inflammatory Drugs-sparing Effect of Symptomatic Slow-acting Drugs for Osteoarthritis in Knee Osteoarthritis Patients | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Sung, Yoon-Kyoung | - |
dc.identifier.doi | 10.4078/jrd.2019.26.3.179 | - |
dc.identifier.scopusid | 2-s2.0-85083712548 | - |
dc.identifier.wosid | 000523560300004 | - |
dc.identifier.bibliographicCitation | 대한류마티스학회지, v.26, no.3, pp.179 - 185 | - |
dc.relation.isPartOf | 대한류마티스학회지 | - |
dc.citation.title | 대한류마티스학회지 | - |
dc.citation.volume | 26 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 179 | - |
dc.citation.endPage | 185 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002474999 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Rheumatology | - |
dc.relation.journalWebOfScienceCategory | Rheumatology | - |
dc.subject.keywordPlus | CHONDROITIN SULFATE | - |
dc.subject.keywordPlus | DICLOFENAC SODIUM | - |
dc.subject.keywordPlus | GLUCOSAMINE | - |
dc.subject.keywordPlus | EFFICACY | - |
dc.subject.keywordPlus | RECOMMENDATIONS | - |
dc.subject.keywordPlus | PREVALENCE | - |
dc.subject.keywordPlus | MANAGEMENT | - |
dc.subject.keywordPlus | DIACEREIN | - |
dc.subject.keywordPlus | BURDEN | - |
dc.subject.keywordPlus | SAFETY | - |
dc.subject.keywordAuthor | Osteoarthritis | - |
dc.subject.keywordAuthor | Symptomatic slow-acting drugs for osteoarthritis | - |
dc.subject.keywordAuthor | Nonsteroidal anti-inflammatory drugs | - |
dc.identifier.url | https://synapse.koreamed.org/articles/1138066 | - |
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