Brain Somatic Mutations in MTOR Disrupt Neuronal Ciliogenesis, Leading to Focal Cortical Dyslamination.
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, S. | - |
dc.contributor.author | Lim, J. | - |
dc.contributor.author | Ramakrishina, S. | - |
dc.contributor.author | Kim, S. | - |
dc.contributor.author | Kim, W. | - |
dc.contributor.author | Lee, J. | - |
dc.contributor.author | Kang, H. | - |
dc.contributor.author | Reiter, J. F. | - |
dc.contributor.author | Kim, D. | - |
dc.contributor.author | Kim, H. | - |
dc.contributor.author | Lee, J. | - |
dc.date.accessioned | 2021-12-24T01:45:23Z | - |
dc.date.available | 2021-12-24T01:45:23Z | - |
dc.date.created | 2021-11-11 | - |
dc.date.issued | 2018-12-09 | - |
dc.identifier.issn | 1059-1524 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/133839 | - |
dc.description.abstract | Focal malformations of cortical development (FMCDs), including focal cortical dysplasia (FCD) and hemimegalencephaly (HME), are major etiologies of pediatric intractable epilepsies exhibiting cortical dyslamination. Brain somatic mutations in MTOR have recently been identified as a major genetic cause of FMCDs. However, the molecular mechanism by which these mutations lead to cortical dyslamination remains poorly understood. Here, using patient tissue, genome-edited cells, and mouse models with brain somatic mutations in MTOR, we discovered that disruption of neuronal ciliogenesis by the mutations underlies cortical dyslamination in FMCDs. We found that abnormal accumulation of OFD1 at centriolar satellites due to perturbed autophagy was responsible for the defective neuronal ciliogenesis. Additionally, we found that disrupted neuronal ciliogenesis accounted for cortical dyslamination in FMCDs by compromising Wnt signals essential for neuronal polarization. Altogether, this study describes a molecular mechanism by which brain somatic mutations in MTOR contribute to the pathogenesis of cortical dyslamination in FMCDs. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | AMER SOC CELL BIOLOGY | - |
dc.title | Brain Somatic Mutations in MTOR Disrupt Neuronal Ciliogenesis, Leading to Focal Cortical Dyslamination. | - |
dc.type | Conference | - |
dc.contributor.affiliatedAuthor | Ramakrishina, S. | - |
dc.identifier.wosid | 000505772700198 | - |
dc.identifier.bibliographicCitation | ASCB/EMBO 2018 meeting, pp.155 | - |
dc.relation.isPartOf | ASCB/EMBO 2018 meeting | - |
dc.relation.isPartOf | MOLECULAR BIOLOGY OF THE CELL | - |
dc.citation.title | ASCB/EMBO 2018 meeting | - |
dc.citation.startPage | 155 | - |
dc.citation.endPage | 155 | - |
dc.citation.conferencePlace | US | - |
dc.citation.conferenceDate | 2018-12-08 | - |
dc.type.rims | CONF | - |
dc.description.journalClass | 1 | - |
dc.identifier.url | https://ascb-embo2018.ascb.org/wp-content/uploads/sites/11/2018/11/PosterAbstracts2018.pdf?_ga=2.91946266.1217033587.1636590165-1944075050.1636590165 | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
222, Wangsimni-ro, Seongdong-gu, Seoul, 04763, Korea+82-2-2220-1365
COPYRIGHT © 2021 HANYANG UNIVERSITY.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.