Characterization and biocompatibility evaluation of artificial blood vessels prepared from pristine poly (Ethylene-glycol-co-1,4-cyclohexane dimethylene-co-isosorbide terephthalate), poly (1, 4 cyclohexane di-methylene-co-isosorbide terephthalate) nanofibers and their blended composition

Abstract

Herein, we prepared three-dimensional artificial blood vessels (ABV) from electrospun pristine Poly (Ethylene-glycol-co-1,4-Cyclohexane di-methylene-co-isosorbide terephthalate) (PEICT), Poly (1, 4 cyclohexane di-methylene-co-isosorbide terephthalate) (PICT) and their blend (BLEND) nanofibers for the first time with three different cross-sectional diameters (0.9, 1.5 and 2.0) mm. Biocompatibility was evaluated by culturing Human Breast Epithelial Cells (MCF-10A) on all samples. Interestingly, collective properties of PICT and PEICT were distinctively imparted onto the surface of BLEND ABVs without reliance upon any special surface treatment. BLEND showed an enhanced wettability and a smooth and compacted morphology making them suitable to hold more (MCF-10A) cells compared to pristine PICT and PEICT. Additionally, BLEND achieved a maximum biodegradation rate as well as the special feature of tensile strength tunability, which reveals its potential and suitability for vascular regeneration and cell culture applications.