Usefulness of risk stratification models for colorectal cancer based on fecal hemoglobin concentration and clinical risk factors
DC Field | Value | Language |
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dc.contributor.author | Park, Chan Hyuk | - |
dc.contributor.author | Jung, Yoon Suk | - |
dc.contributor.author | Kim, Nam Hee | - |
dc.contributor.author | Park, Jung Ho | - |
dc.contributor.author | Park, Dong Il | - |
dc.contributor.author | Sohn, Chong Il | - |
dc.date.accessioned | 2021-08-02T11:30:30Z | - |
dc.date.available | 2021-08-02T11:30:30Z | - |
dc.date.created | 2021-05-11 | - |
dc.date.issued | 2019-06 | - |
dc.identifier.issn | 0016-5107 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/13479 | - |
dc.description.abstract | Background and Aims We aimed to develop risk stratification models for advanced colorectal neoplasia (ACRN) and colorectal cancer (CRC) based on fecal hemoglobin (f-Hb) concentration and clinical risk factors. Methods We reviewed screenees aged ≥50 years who underwent fecal immunochemical test (FIT) and colonoscopy and developed risk-scoring models for ACRN and CRC using logistic regression analysis. Participants were classified into low- (risk lower than that in FIT-negative individuals), intermediate- (risk higher than that in FIT-negative but lower than that in FIT-positive individuals), high- (risk similar to that in FIT-positive individuals), and very-high- (risk higher than that in FIT-positive individuals) risk groups. Results Of 3733 participants, 367 (9.8%) and 70 (1.9%) had ACRN and CRC, respectively. On multivariable analysis, age (ß = .043/y), former smoker (ß = .401), current smoker (ß = .841), diabetes (ß = .097), and square root of f-Hb concentration (ß = .071) were significantly associated with ACRN. In terms of CRC, age (ß = .035/y) and square root of f-Hb concentration (ß = .004) were associated factors. After point assignments based on the regression coefficient, we could classify screenees as low-, intermediate-, high-, and very-high-risk groups. ACRN was identified in 2.9%, 5.3%, 16.2%, and 35.7% of screenees in the low-, intermediate-, high-, and very-high-risk groups, respectively. CRC was identified in .1%, .5%, 3.9%, and 11.1% of screenees in the low-, intermediate-, high-, and very-high-risk groups, respectively. Conclusions The proposed models can effectively stratify the risk for ACRN and CRC and provide accurate information on this risk in individuals who undergo FIT. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MOSBY-ELSEVIER | - |
dc.title | Usefulness of risk stratification models for colorectal cancer based on fecal hemoglobin concentration and clinical risk factors | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, Chan Hyuk | - |
dc.identifier.doi | 10.1016/j.gie.2019.02.023 | - |
dc.identifier.scopusid | 2-s2.0-85064248382 | - |
dc.identifier.wosid | 000468106800019 | - |
dc.identifier.bibliographicCitation | GASTROINTESTINAL ENDOSCOPY, v.89, no.6, pp.1204 - 1211.e1 | - |
dc.relation.isPartOf | GASTROINTESTINAL ENDOSCOPY | - |
dc.citation.title | GASTROINTESTINAL ENDOSCOPY | - |
dc.citation.volume | 89 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 1204 | - |
dc.citation.endPage | 1211.e1 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Gastroenterology & Hepatology | - |
dc.relation.journalWebOfScienceCategory | Gastroenterology & Hepatology | - |
dc.subject.keywordPlus | SOCIETY TASK-FORCE | - |
dc.subject.keywordPlus | PREDICTION | - |
dc.subject.keywordPlus | NEOPLASIA | - |
dc.subject.keywordPlus | RECOMMENDATIONS | - |
dc.subject.keywordPlus | TESTS | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0016510719301385?via%3Dihub | - |
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