Mismatch Negativity and Cortical Thickness in Patients With Schizophrenia and Bipolar Disorder
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Sungkean | - |
dc.contributor.author | Jeon, Hyeonjin | - |
dc.contributor.author | Jang, Kuk-In | - |
dc.contributor.author | Kim, Yong-Wook | - |
dc.contributor.author | Im, Chang-Hwan | - |
dc.contributor.author | Lee, Seung-Hwan | - |
dc.date.accessioned | 2022-04-01T09:20:54Z | - |
dc.date.available | 2022-04-01T09:20:54Z | - |
dc.date.issued | 2019-03 | - |
dc.identifier.issn | 0586-7614 | - |
dc.identifier.issn | 1745-1701 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/136085 | - |
dc.description.abstract | Introduction Mismatch negativity (MMN) is a measure of automatic neurophysiological brain processes for detecting unexpected sensory stimuli. This study investigated MMN reduction in patients with schizophrenia and bipolar disorder and examined whether cortical thickness is associated with MMN, for exploratory purposes. Methods Electroencephalograms were recorded in 38 patients with schizophrenia, 37 patients with bipolar disorder, and 32 healthy controls (HCs) performing a passive auditory oddball paradigm. All participants underwent T1 structural magnetic resonance imaging scanning to investigate the cortical thickness of MMN-generating regions. Average MMN amplitudes from the frontocentral electrodes were analyzed. Results Patients with schizophrenia and bipolar disorder exhibited significantly reduced MMN amplitude compared with HCs. In bipolar disorder, we found intermediate MMN amplitude among the groups. Average MMN and cortical thickness of the right superior temporal gyrus (STG) were significantly negatively correlated in patients with schizophrenia. In patients with bipolar disorder, average MMN was significantly correlated with cortical thickness of the left anterior cingulate cortex and the right STG. MMN showed negative correlations with social and occupational functioning in schizophrenia, and with the Korean auditory verbal learning test for delayed recall in bipolar disorder. Conclusions MMN reduction was associated with cortical thinning in frontal and temporal areas in patients, particularly with an auditory verbal hallucination-related region in schizophrenia and emotion-related regions in bipolar disorder. MMN was associated with functional outcomes in schizophrenia, whereas it was associated with neurocognition in bipolar disorder. | - |
dc.format.extent | 11 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | OXFORD UNIV PRESS | - |
dc.title | Mismatch Negativity and Cortical Thickness in Patients With Schizophrenia and Bipolar Disorder | - |
dc.type | Article | - |
dc.publisher.location | 영국 | - |
dc.identifier.doi | 10.1093/schbul/sby041 | - |
dc.identifier.scopusid | 2-s2.0-85062622673 | - |
dc.identifier.wosid | 000461163300022 | - |
dc.identifier.bibliographicCitation | SCHIZOPHRENIA BULLETIN, v.45, no.2, pp 425 - 435 | - |
dc.citation.title | SCHIZOPHRENIA BULLETIN | - |
dc.citation.volume | 45 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 425 | - |
dc.citation.endPage | 435 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | ssci | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Psychiatry | - |
dc.relation.journalWebOfScienceCategory | Psychiatry | - |
dc.subject.keywordPlus | SUPERIOR TEMPORAL GYRUS | - |
dc.subject.keywordPlus | AUDITORY SENSORY MEMORY | - |
dc.subject.keywordPlus | GRAY-MATTER VOLUME | - |
dc.subject.keywordPlus | 1ST-EPISODE PSYCHOSIS | - |
dc.subject.keywordPlus | CONFIDENCE-INTERVALS | - |
dc.subject.keywordPlus | PREFRONTAL CORTEX | - |
dc.subject.keywordPlus | NEURAL BASIS | - |
dc.subject.keywordPlus | METAANALYSIS | - |
dc.subject.keywordPlus | DYSFUNCTION | - |
dc.subject.keywordPlus | MMN | - |
dc.subject.keywordAuthor | mismatch negativity | - |
dc.subject.keywordAuthor | cortical thickness | - |
dc.subject.keywordAuthor | schizophrenia | - |
dc.subject.keywordAuthor | bipolar disorder | - |
dc.identifier.url | https://academic.oup.com/schizophreniabulletin/article/45/2/425/4978295 | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
222, Wangsimni-ro, Seongdong-gu, Seoul, 04763, Korea+82-2-2220-1365
COPYRIGHT © 2021 HANYANG UNIVERSITY.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.