Oligoarginine-modified chitosan for siRNA delivery
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Soyeon | - |
dc.contributor.author | Lee, Sang Kyung | - |
dc.contributor.author | Lee, Kuen Yong | - |
dc.date.accessioned | 2022-04-01T10:03:42Z | - |
dc.date.available | 2022-04-01T10:03:42Z | - |
dc.date.created | 2022-01-24 | - |
dc.date.issued | 2011-09-14 | - |
dc.identifier.issn | 0168-3659 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/136550 | - |
dc.description.abstract | Small interfering RNA (siRNA) has been widely investigated as a potential therapeutic for treatment of various diseases. However, naked siRNA is rapidly degraded by nucleases, showing poor cellular uptake and low transfection efficiency. Chitosan-based nanoparticles have been extensively exploited as a gene delivery carrier due to low toxicity and positively charged amino groups of chitosan. In this study, we synthesized 9R-modified chitosan and used it to form stable nanoparticles in the presence of siRNA. Various physicochemical properties of the nanoparticles, including size, surface charge, and complex forming ability, were investigated. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | Soochow University Biomedical Polymers Laboratory | - |
dc.title | Oligoarginine-modified chitosan for siRNA delivery | - |
dc.type | Conference | - |
dc.contributor.affiliatedAuthor | Lee, Kuen Yong | - |
dc.identifier.scopusid | 2-s2.0-84861210514 | - |
dc.identifier.wosid | 000299125600111 | - |
dc.identifier.bibliographicCitation | 1st Symposium on Innovative Polymers for Controlled Delivery, pp.E165 - E166 | - |
dc.relation.isPartOf | 1st Symposium on Innovative Polymers for Controlled Delivery | - |
dc.relation.isPartOf | JOURNAL OF CONTROLLED RELEASE | - |
dc.citation.title | 1st Symposium on Innovative Polymers for Controlled Delivery | - |
dc.citation.startPage | E165 | - |
dc.citation.endPage | E166 | - |
dc.citation.conferencePlace | CC | - |
dc.citation.conferencePlace | Suzhou, PEOPLES R CHINA | - |
dc.citation.conferenceDate | 2010-09-14 | - |
dc.type.rims | CONF | - |
dc.description.journalClass | 1 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0168365911006791?via%3Dihub | - |
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