Visual Field Characteristics in East Asian Patients With Occult Macular Dystrophy (Miyake Disease): EAOMD Report No. 3
DC Field | Value | Language |
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dc.contributor.author | Ahn, Seong Joon | - |
dc.contributor.author | Yang, Lizhu | - |
dc.contributor.author | Tsunoda, Kazushige | - |
dc.contributor.author | Kondo, Mineo | - |
dc.contributor.author | Fujinami-Yokokawa, Yu | - |
dc.contributor.author | Nakamura, Natsuko | - |
dc.contributor.author | Iwata, Takeshi | - |
dc.contributor.author | Kim, Min Seok | - |
dc.contributor.author | Mun, Yongseok | - |
dc.contributor.author | Park, Jun Young | - |
dc.contributor.author | Joo, Kwangsic | - |
dc.contributor.author | Park, Kyu Hyung | - |
dc.contributor.author | Miyake, Yozo | - |
dc.contributor.author | Sui, Ruifang | - |
dc.contributor.author | Fujinami, Kaoru | - |
dc.contributor.author | Woo, Se Joon | - |
dc.date.accessioned | 2022-07-06T02:14:18Z | - |
dc.date.available | 2022-07-06T02:14:18Z | - |
dc.date.created | 2022-01-26 | - |
dc.date.issued | 2022-01 | - |
dc.identifier.issn | 0146-0404 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/138438 | - |
dc.description.abstract | PURPOSE. The purpose of this study was to investigate the perimetric features and their associations with structural and functional features in patients with RP1L1-associated occult macular dystrophy (OMD; i.e. Miyake disease). METHODS. In this international, multicenter, retrospective cohort study, 76 eyes of 38 patients from an East Asian cohort of patients with RP1L1-associated OMD were recruited. Visual field tests were performed using standard automated perimetry, and the patients were classified into three perimetric groups based on the visual field findings: central scotoma, other scotoma (e.g. paracentral scotoma), and no scotoma. The association of the structural and functional findings with the perimetric findings was evaluated. RESULTS. Fifty-four eyes (71.1%) showed central scotoma, 14 (18.4%) had other scotomata, and 8 (10.5%) had no scotoma. Central scotoma was mostly noted in both eyes (96.3%) and within the central 10 degrees (90.7%). Among the three perimetric groups, there were significant differences in visual symptoms, best-corrected visual acuity (BCVA), and structural phenotypes (i.e. severity of photoreceptor changes). The central scotoma group showed worse BCVA often with severe structural abnormalities (96.3%) and a pathogenic variant of p.R45W (72.2%). The multifocal electroretinogram (mfERG) groups largely corresponded with the perimetric groups; however, 8 (10.5%) of 76 eyes showed mfERG abnormalities preceding typical central scotoma. CONCLUSIONS. The patterns of scotoma with different clinical severity were first identified in occult macular dystrophy, and central scotoma, a severe pattern, was most frequently observed. These perimetric patterns were associated with the severity of BCVA, structural phenotypes, genotype, and objective functional characteristics which may precede in some cases. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ASSOC RESEARCH VISION OPHTHALMOLOGY INC | - |
dc.title | Visual Field Characteristics in East Asian Patients With Occult Macular Dystrophy (Miyake Disease): EAOMD Report No. 3 | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Ahn, Seong Joon | - |
dc.identifier.doi | 10.1167/iovs.63.1.12 | - |
dc.identifier.scopusid | 2-s2.0-85123102583 | - |
dc.identifier.wosid | 000742672600001 | - |
dc.identifier.bibliographicCitation | Investigative Ophthalmology and Visual Science, v.63, no.1, pp.1 - 9 | - |
dc.relation.isPartOf | Investigative Ophthalmology and Visual Science | - |
dc.citation.title | Investigative Ophthalmology and Visual Science | - |
dc.citation.volume | 63 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 9 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Ophthalmology | - |
dc.relation.journalWebOfScienceCategory | Ophthalmology | - |
dc.subject.keywordPlus | ISCEV STANDARD | - |
dc.subject.keywordPlus | RP1L1 | - |
dc.subject.keywordPlus | MUTATIONS | - |
dc.subject.keywordPlus | COHORT | - |
dc.subject.keywordAuthor | Miyake disease | - |
dc.subject.keywordAuthor | occult macular dystrophy | - |
dc.subject.keywordAuthor | RP1L1 | - |
dc.subject.keywordAuthor | visual fields | - |
dc.identifier.url | https://iovs.arvojournals.org/article.aspx?articleid=2778239 | - |
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