Effects of inhaled corticosteroid/long-acting β2-agonist combination on the airway microbiome of patients with chronic obstructive pulmonary disease: A randomized controlled clinical trial (DISARM)
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Leitao, Filho Fernando Sergio | - |
dc.contributor.author | Takiguchi, Hiroto | - |
dc.contributor.author | Akata, Kentaro | - |
dc.contributor.author | Ra, Seung Won | - |
dc.contributor.author | Moon, Ji-Yong | - |
dc.contributor.author | Kim, Hyun Kuk | - |
dc.contributor.author | Cho, Yuji | - |
dc.contributor.author | Yamasaki, Kei | - |
dc.contributor.author | Milne, Stephen | - |
dc.contributor.author | Yang, Julia | - |
dc.contributor.author | Tony, Yang Cheng Wei | - |
dc.contributor.author | Li, Xuan | - |
dc.contributor.author | Nislow, Corey | - |
dc.contributor.author | van, Eeden Stephan F | - |
dc.contributor.author | Shaipanich, Tawimas | - |
dc.contributor.author | Lam, Stephen | - |
dc.contributor.author | Leung, Janice M. | - |
dc.contributor.author | Sin, Don D. | - |
dc.date.accessioned | 2022-07-06T02:23:24Z | - |
dc.date.available | 2022-07-06T02:23:24Z | - |
dc.date.created | 2022-01-05 | - |
dc.date.issued | 2021-11 | - |
dc.identifier.issn | 1073-449X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/138610 | - |
dc.description.abstract | Rationale: Inhaled corticosteroids (ICS) are commonly prescribed with long-acting b2-agonists (LABA) in chronic obstructive pulmonary disease (COPD). To date, the effects of ICS therapy on the airway microbiome in COPD are unknown. Objectives: To determine the effects of ICS/LABA on the airway microbiome of patients with COPD. Methods: Clinically stable patients with COPD were enrolled into a 4-week run-in period during which ICS was discontinued and all participants were placed on formoterol (Form) 12 mg twice daily (BID). The participants were then randomized to budesonide/ formoterol (Bud 1 Form; 400/12 mg BID), fluticasone/salmeterol (Flu 1 Salm; 250/50 mg BID), or formoterol only (12 mg BID) for 12 weeks. Participants underwent bronchoscopy before and after the 12-week treatment period. The primary endpoint was the comparison of changes in the airway microbiome over the trial period between the ICS/LABA and LABA-only groups. Measurements and Main Results: Sixty-three participants underwent randomization: Bud 1 Form (n = 20), Flu 1 Salm (n = 22), and Form (n = 21) groups; 56 subjects completed all visits. After the treatment period, changes in a-diversity were significantly different across groups, especially between Flu 1 Salm and Form groups (Drichness: P = 0.02; DShannon index: P = 0.03). Longitudinal differential abundance analyses revealed more pronounced microbial shifts from baseline in the fluticasone (vs. budesonide or formoterol only) group. Conclusions: Fluticasone-based ICS/LABA therapy modifies the airway microbiome in COPD, leading to a relative reduction in a-diversity and a greater number of bacterial taxa changes. These data may have implications in patients who develop pneumonia on ICS. Clinical trial registered with www.clinicaltrials.gov (NCT02833480). | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | American Thoracic Society | - |
dc.title | Effects of inhaled corticosteroid/long-acting β2-agonist combination on the airway microbiome of patients with chronic obstructive pulmonary disease: A randomized controlled clinical trial (DISARM) | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Moon, Ji-Yong | - |
dc.identifier.doi | 10.1164/rccm.202102-0289OC | - |
dc.identifier.scopusid | 2-s2.0-85120405099 | - |
dc.identifier.wosid | 000739004800012 | - |
dc.identifier.bibliographicCitation | American Journal of Respiratory and Critical Care Medicine, v.204, no.10, pp.1143 - 1152 | - |
dc.relation.isPartOf | American Journal of Respiratory and Critical Care Medicine | - |
dc.citation.title | American Journal of Respiratory and Critical Care Medicine | - |
dc.citation.volume | 204 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 1143 | - |
dc.citation.endPage | 1152 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalResearchArea | Respiratory System | - |
dc.relation.journalWebOfScienceCategory | Critical Care Medicine | - |
dc.relation.journalWebOfScienceCategory | Respiratory System | - |
dc.subject.keywordPlus | LUNG MICROBIOME | - |
dc.subject.keywordPlus | PNEUMONIA | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordAuthor | COPD | - |
dc.subject.keywordAuthor | inhaled corticosteroids | - |
dc.subject.keywordAuthor | airway microbiome | - |
dc.subject.keywordAuthor | 16S rRNA gene | - |
dc.identifier.url | https://www.atsjournals.org/doi/10.1164/rccm.202102-0289OC | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
222, Wangsimni-ro, Seongdong-gu, Seoul, 04763, Korea+82-2-2220-1365
COPYRIGHT © 2021 HANYANG UNIVERSITY.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.