Effect of Metformin on Myocardial Injury Induced by Hepatic Ischemia-Reperfusion in Rats
DC Field | Value | Language |
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dc.contributor.author | An, Wen An | - |
dc.contributor.author | Kang, Ju-Seop | - |
dc.date.accessioned | 2022-07-06T04:10:17Z | - |
dc.date.available | 2022-07-06T04:10:17Z | - |
dc.date.created | 2022-06-03 | - |
dc.date.issued | 2022-04 | - |
dc.identifier.issn | 1663-9812 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/138786 | - |
dc.description.abstract | Background: There is no effective medication for treatment or prevention of hepatic ischemia-reperfusion (HIR) injury caused by liver transplantation and hepatectomy. This study aimed to investigate the therapeutic effects of metformin on HIR injury and related myocardial injury in rats. Methods: Wistar male rats were randomly divided into four groups: sham group, ischemia-reperfusion group, and IR group treated with metformin 150 mg/kg and 100 mg/kg. Wistar male rats were administered metformin 150 mg/kg, 100 mg/kg or saline 30 min pre-operative and underwent 15 min ischemia and 6 h reperfusion (n = 4). Results: Metformin significantly alleviates the injury caused by HIR. Administration of metformin resulted in a significant reduction in the serum levels of alanine transaminase and aspartate transaminase and the activity of malondialdehyde, creatine kinase-MB, and lactate dehydrogenase but maintained high catalase and superoxide dismutase activity. Metformin significantly inhibited the IR-induced elevation of tumor necrosis factor-α in liver and heart tissue. Conclusion: Metformin can alleviate hepatic and myocardial injury induced by IR by inhibiting oxidative stress. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | Frontiers Media S.A. | - |
dc.title | Effect of Metformin on Myocardial Injury Induced by Hepatic Ischemia-Reperfusion in Rats | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kang, Ju-Seop | - |
dc.identifier.doi | 10.3389/fphar.2022.822743 | - |
dc.identifier.scopusid | 2-s2.0-85128584579 | - |
dc.identifier.wosid | 000806245200001 | - |
dc.identifier.bibliographicCitation | Frontiers in Pharmacology, v.13, pp.1 - 9 | - |
dc.relation.isPartOf | Frontiers in Pharmacology | - |
dc.citation.title | Frontiers in Pharmacology | - |
dc.citation.volume | 13 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 9 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | ISCHEMIA/REPERFUSION INJURY | - |
dc.subject.keywordPlus | FATTY LIVER | - |
dc.subject.keywordPlus | CARDIOPROTECTION | - |
dc.subject.keywordPlus | PRETREATMENT | - |
dc.subject.keywordPlus | INFARCTION | - |
dc.subject.keywordPlus | AMPK | - |
dc.subject.keywordAuthor | hepatic injury | - |
dc.subject.keywordAuthor | hepatic ischemia-reperfusion | - |
dc.subject.keywordAuthor | metformin | - |
dc.subject.keywordAuthor | myocardial injury | - |
dc.subject.keywordAuthor | oxidative stress | - |
dc.identifier.url | https://www.frontiersin.org/articles/10.3389/fphar.2022.822743/full | - |
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