Chronic Obstructive Pulmonary Disease is Associated with a More Symptomatic Burden and Severe Presentation of COVID-19: A Korean National COVID-19 Cohort Study
DC Field | Value | Language |
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dc.contributor.author | Kim, Youlim | - |
dc.contributor.author | Lee, Hyun | - |
dc.contributor.author | Lee, Sun-Kyung | - |
dc.contributor.author | Yang, Bumhee | - |
dc.contributor.author | Choi, Hayoung | - |
dc.contributor.author | Park, Dong Won | - |
dc.contributor.author | Park, Tai Sun | - |
dc.contributor.author | Moon, Ji Yong | - |
dc.contributor.author | Kim, Tae Hyung | - |
dc.contributor.author | Sohn, Jang Won | - |
dc.contributor.author | Yoon, Ho Joo | - |
dc.contributor.author | Kim, Sang Heon | - |
dc.date.accessioned | 2022-07-06T08:37:08Z | - |
dc.date.available | 2022-07-06T08:37:08Z | - |
dc.date.created | 2022-04-06 | - |
dc.date.issued | 2022-03 | - |
dc.identifier.issn | 0040-8727 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/139287 | - |
dc.description.abstract | Insufficient data are available on comprehensive evaluation of demographics, symptoms or signs, laboratory findings, and disease course in patients with coronavirus disease 2019 (COVID-19) and chronic obstructive pulmonary disease (COPD). We aimed to evaluate whether COPD patients are more prone to severe COVID-19 compared with those without COPD. We also investigate the clinical characteristics and disease course of COVID-19 in patients with COPD versus those without COPD. Patients were selected from a Korean nationwide cohort of 5,628 patients with confirmed COVID-19 and who had completed treatment or quarantine by April 30, 2020; 3,673 patients aged 40 years or older were included in this study. COPD was diagnosed using patient reports of physician-diagnosed COPD. During the study period, all patients with COVID-19 in Korea were hospitalized following the national health policy. Of the study participants, 38 (1.0%) had COPD. Regarding initial symptoms, COPD patients with COVID-19 showed greater sputum production (50.0% vs. 29.8%, p < 0.01) and dyspnea (36.8% vs. 14.9%, p < 0.01) than those without COPD. In addition, patients with COPD were more likely to receive oxygen therapy or non-invasive ventilation (29.0% vs. 13.7%, p = 0.01) and had a higher mortality (21.1% vs. 6.4%, p < 0.01) than those without COPD. After adjusting for age, sex, body mass index, and comorbidities, COPD patients showed increased risk of severe COVID-19 compared with those without COPD. Our nationwide study showed that COVID-19 patients with COPD have higher symptomatic burden and more severe disease course than those without COPD. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | TOHOKU UNIV MEDICAL PRESS | - |
dc.title | Chronic Obstructive Pulmonary Disease is Associated with a More Symptomatic Burden and Severe Presentation of COVID-19: A Korean National COVID-19 Cohort Study | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Hyun | - |
dc.contributor.affiliatedAuthor | Park, Dong Won | - |
dc.contributor.affiliatedAuthor | Park, Tai Sun | - |
dc.contributor.affiliatedAuthor | Moon, Ji Yong | - |
dc.contributor.affiliatedAuthor | Kim, Tae Hyung | - |
dc.contributor.affiliatedAuthor | Sohn, Jang Won | - |
dc.contributor.affiliatedAuthor | Yoon, Ho Joo | - |
dc.contributor.affiliatedAuthor | Kim, Sang Heon | - |
dc.identifier.doi | 10.1620/tjem.256.209 | - |
dc.identifier.scopusid | 2-s2.0-85126864189 | - |
dc.identifier.wosid | 000782343500003 | - |
dc.identifier.bibliographicCitation | TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE, v.256, no.3, pp.209 - 214 | - |
dc.relation.isPartOf | TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE | - |
dc.citation.title | TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE | - |
dc.citation.volume | 256 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 209 | - |
dc.citation.endPage | 214 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.subject.keywordPlus | adult | - |
dc.subject.keywordPlus | age | - |
dc.subject.keywordPlus | Article | - |
dc.subject.keywordPlus | body mass | - |
dc.subject.keywordPlus | chronic obstructive lung disease | - |
dc.subject.keywordPlus | clinical feature | - |
dc.subject.keywordPlus | cohort analysis | - |
dc.subject.keywordPlus | comorbidity | - |
dc.subject.keywordPlus | controlled study | - |
dc.subject.keywordPlus | coronavirus disease 2019 | - |
dc.subject.keywordPlus | disease association | - |
dc.subject.keywordPlus | disease burden | - |
dc.subject.keywordPlus | disease severity | - |
dc.subject.keywordPlus | dyspnea | - |
dc.subject.keywordPlus | female | - |
dc.subject.keywordPlus | health care policy | - |
dc.subject.keywordPlus | hospital patient | - |
dc.subject.keywordPlus | human | - |
dc.subject.keywordPlus | infection risk | - |
dc.subject.keywordPlus | Korea | - |
dc.subject.keywordPlus | major clinical study | - |
dc.subject.keywordPlus | male | - |
dc.subject.keywordPlus | mortality | - |
dc.subject.keywordPlus | noninvasive ventilation | - |
dc.subject.keywordPlus | oxygen therapy | - |
dc.subject.keywordPlus | public health | - |
dc.subject.keywordPlus | quarantine | - |
dc.subject.keywordPlus | sex difference | - |
dc.subject.keywordPlus | sputum analysis | - |
dc.subject.keywordPlus | chronic obstructive lung disease | - |
dc.subject.keywordPlus | complication | - |
dc.subject.keywordPlus | disease exacerbation | - |
dc.subject.keywordPlus | South Korea | - |
dc.subject.keywordAuthor | COPD | - |
dc.subject.keywordAuthor | COVID-19 infection | - |
dc.subject.keywordAuthor | disease severity | - |
dc.subject.keywordAuthor | mortality | - |
dc.subject.keywordAuthor | symptom burden | - |
dc.identifier.url | https://www.jstage.jst.go.jp/article/tjem/256/3/256_256.209/_article | - |
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