Association Between Obesity and Cardiovascular Disease in Elderly Patients With Diabetes: A Retrospective Cohort Study
DC Field | Value | Language |
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dc.contributor.author | Hong, Sangmo | - |
dc.contributor.author | Park, Jung Hwan | - |
dc.contributor.author | Han, Kyungdo | - |
dc.contributor.author | Lee, Chang Beom | - |
dc.contributor.author | Kim, Dong Sun | - |
dc.contributor.author | Yu, Sung Hoon | - |
dc.date.accessioned | 2022-07-06T10:19:29Z | - |
dc.date.available | 2022-07-06T10:19:29Z | - |
dc.date.created | 2022-03-07 | - |
dc.date.issued | 2022-02 | - |
dc.identifier.issn | 0021-972X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/139587 | - |
dc.description.abstract | CONTEXT: Some studies have suggested that patients with type 2 diabetes mellitus (T2DM) concomitant with obesity have better clinical outcomes than normal-weight patients with T2DM. OBJECTIVE: We evaluated associations among obesity, cardiovascular disease (CVD) events, and mortality in elderly patients with T2DM without CVD. METHODS: This retrospective observational study from 2009 to 2017, with a mean follow-up of 7.26 years, included 249 903 elderly (≥ 65 years) patients with T2DM and no preexisting CVD from the Korean National Health Information Database. We categorized subjects according to body mass index (BMI) and waist circumference (WC) and analyzed a composite of stroke, myocardial infarction, and all-cause death using Cox proportional hazards regression analysis, adjusting for baseline covariates. RESULTS: The incidence rate of composite primary outcomes was 30.95/1000 person-years. The primary outcome risk had an L-shaped and a U-shaped association with BMI and WC, respectively. In the multivariable Cox proportional hazard models, the risk of primary composite outcomes in the highest BMI group (≥ 30 kg/m2; hazard ratio [HR] = 0.824; 95% CI, 0.794-0.855) was lower than in the normal BMI group (≥ 18.5 and < 23 kg/m2). Conversely, that in the highest WC group (≥ 100 cm/≥ 95 cm; men/women; HR = 1.434; 95% CI, 1.384-1.486) was higher than in the normal WC group (< 90 cm/< 85 cm; men/women). CONCLUSION: Our study with elderly patients with diabetes results suggest that while BMI is an inadequate risk indicator for outcomes related to obesity, WC is a suitable alternative. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | NLM (Medline) | - |
dc.title | Association Between Obesity and Cardiovascular Disease in Elderly Patients With Diabetes: A Retrospective Cohort Study | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Hong, Sangmo | - |
dc.contributor.affiliatedAuthor | Park, Jung Hwan | - |
dc.contributor.affiliatedAuthor | Lee, Chang Beom | - |
dc.contributor.affiliatedAuthor | Kim, Dong Sun | - |
dc.contributor.affiliatedAuthor | Yu, Sung Hoon | - |
dc.identifier.doi | 10.1210/clinem/dgab714 | - |
dc.identifier.scopusid | 2-s2.0-85123647614 | - |
dc.identifier.wosid | 000749673300007 | - |
dc.identifier.bibliographicCitation | The Journal of clinical endocrinology and metabolism, v.107, no.2, pp.e515 - e527 | - |
dc.relation.isPartOf | The Journal of clinical endocrinology and metabolism | - |
dc.citation.title | The Journal of clinical endocrinology and metabolism | - |
dc.citation.volume | 107 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | e515 | - |
dc.citation.endPage | e527 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Endocrinology & Metabolism | - |
dc.relation.journalWebOfScienceCategory | Endocrinology & Metabolism | - |
dc.subject.keywordPlus | BODY-MASS INDEX | - |
dc.subject.keywordPlus | 3RD NATIONAL-HEALTH | - |
dc.subject.keywordPlus | BETA-CELL FUNCTION | - |
dc.subject.keywordPlus | WAIST CIRCUMFERENCE | - |
dc.subject.keywordPlus | WEIGHT-LOSS | - |
dc.subject.keywordPlus | MORTALITY | - |
dc.subject.keywordPlus | PARADOX | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordPlus | INTERVENTION | - |
dc.subject.keywordPlus | INDIVIDUALS | - |
dc.subject.keywordAuthor | cardiovascular disease | - |
dc.subject.keywordAuthor | elderly | - |
dc.subject.keywordAuthor | mortality | - |
dc.subject.keywordAuthor | obesity | - |
dc.subject.keywordAuthor | waist circumference | - |
dc.identifier.url | https://academic.oup.com/jcem/article/107/2/e515/6379050 | - |
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