Increasing Age Associated with Higher Dipeptidyl Peptidase-4 Inhibition Rate Is a Predictive Factor for Efficacy of Dipeptidyl Peptidase-4 Inhibitors
DC Field | Value | Language |
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dc.contributor.author | Hong, Sangmo | - |
dc.contributor.author | Jung, Chang Hee | - |
dc.contributor.author | Han, Song | - |
dc.contributor.author | Park, Cheol-Young | - |
dc.date.accessioned | 2022-07-06T10:39:11Z | - |
dc.date.available | 2022-07-06T10:39:11Z | - |
dc.date.created | 2022-03-07 | - |
dc.date.issued | 2022-01 | - |
dc.identifier.issn | 2233-6079 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/139809 | - |
dc.description.abstract | Background: It is not known which type 2 diabetes mellitus (T2DM) patients would most benefit from dipeptidyl peptidase-4 (DPP-4) inhibitor treatment. We aimed to investigate the predictors of response to DPP-4 inhibitors considering degree of DPP-4 inhibition. Methods: This study is a post hoc analysis of a 24-week, randomized, double-blind, phase III trial that compared the efficacy and safety of a DPP-4 inhibitor (gemigliptin vs. sitagliptin) in patients with T2DM. Subjects were classified into tertiles of T1 < 65.26%, T2 = 65.26%-76.35%, and T3 >= 76.35% by DPP-4 inhibition. We analyzed the change from baseline in glycosylated hemoglobin (HbA1c) according to DPP-4 inhibition with multiple linear regression adjusting for age, ethnicity, body mass index, baseline HbA1c, and DPP-4 activity at baseline. Results: The mean age was greater in the high tertile group compared with the low tertile group (T1: 49.8 +/- 8.3 vs. T2: 53.1 +/- 10.5 vs. T3: 55.3 +/- 9.5, P<0.001) of DPP-4 inhibition. Although HbA1c at baseline was not different among tertiles of DPP-4 inhibition (P=0.398), HbA1c after 24-week treatment was lower in the higher tertile compares to the lower tertile (T1: 7.30%+/- 0.88% vs. T2: 7.12%+/- 0.78% vs. T3: 7.00%+/- 0.78%, P=0.021). In multiple regression analysis, DPP-4 enzyme inhibition rate was not a significant determent for HbA1c reduction due to age. In subgroup analysis by tertile of DPP-4 inhibition, age was the only significant predictor and only in the highest tertile (R-2=0.281, B=-0.014, P=0.024). Conclusion: This study showed that HbA1c reduction by DPP-4 inhibitor was associated with increasing age, and this association was linked with higher DPP-4 inhibition. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | KOREAN DIABETES ASSOC | - |
dc.title | Increasing Age Associated with Higher Dipeptidyl Peptidase-4 Inhibition Rate Is a Predictive Factor for Efficacy of Dipeptidyl Peptidase-4 Inhibitors | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Hong, Sangmo | - |
dc.identifier.doi | 10.4093/DMJ.2020.0253 | - |
dc.identifier.scopusid | 2-s2.0-85124433988 | - |
dc.identifier.wosid | 000807972700006 | - |
dc.identifier.bibliographicCitation | DIABETES & METABOLISM JOURNAL, v.46, no.1, pp.63 - 70 | - |
dc.relation.isPartOf | DIABETES & METABOLISM JOURNAL | - |
dc.citation.title | DIABETES & METABOLISM JOURNAL | - |
dc.citation.volume | 46 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 63 | - |
dc.citation.endPage | 70 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002808258 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Endocrinology & Metabolism | - |
dc.relation.journalWebOfScienceCategory | Endocrinology & Metabolism | - |
dc.subject.keywordPlus | BETA-CELL FUNCTION | - |
dc.subject.keywordPlus | TYPE-2 DIABETES-MELLITUS | - |
dc.subject.keywordPlus | DOUBLE-BLIND | - |
dc.subject.keywordPlus | GEMIGLIPTIN | - |
dc.subject.keywordPlus | SITAGLIPTIN | - |
dc.subject.keywordPlus | SAFETY | - |
dc.subject.keywordPlus | SAXAGLIPTIN | - |
dc.subject.keywordPlus | MULTICENTER | - |
dc.subject.keywordPlus | MANAGEMENT | - |
dc.subject.keywordPlus | TRIAL | - |
dc.subject.keywordAuthor | Aged | - |
dc.subject.keywordAuthor | Diabetes mellitus | - |
dc.subject.keywordAuthor | Dipeptidyl-peptidase IV inhibitors | - |
dc.subject.keywordAuthor | Glycated hemoglobin A | - |
dc.identifier.url | https://www.e-dmj.org/journal/view.php?doi=10.4093/dmj.2020.0253 | - |
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