Proliferation of Mouse Prostate Cancer Cells Inflamed by Trichomonas vaginalis
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김상수 | - |
dc.contributor.author | 김규식 | - |
dc.contributor.author | 한익환 | - |
dc.contributor.author | 김예슬 | - |
dc.contributor.author | 방성식 | - |
dc.contributor.author | 김정현 | - |
dc.contributor.author | 김용석 | - |
dc.contributor.author | 최수연 | - |
dc.contributor.author | 류재숙 | - |
dc.date.accessioned | 2022-07-06T10:57:31Z | - |
dc.date.available | 2022-07-06T10:57:31Z | - |
dc.date.created | 2022-01-06 | - |
dc.date.issued | 2021-12 | - |
dc.identifier.issn | 0023-4001 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/140117 | - |
dc.description.abstract | Our objective was to investigate whether inflammatory microenvironment induced by Trichomonas vaginalis infection can stimulate proliferation of prostate cancer (PCa) cells in vitro and in vivo mouse experiments. The production of CXCL1 and CCL2 increased when cells of the mouse PCa cells (TRAMP-C2 cell line) were infected with live T. vaginalis. T. vaginalis-conditioned medium (TCM) prepared from co-culture of PCa cells and T. vaginalis increased PCa cells migration, proliferation and invasion. The cytokine receptors (CXCR2, CCR2, gp130) were expressed higher on the PCa cells treated with TCM. Pretreatment of PCa cells with antibodies to these cytokine receptors significantly reduced the proliferation, mobility and invasiveness of PCa cells, indicating that TCM has its effect through cytokine-cytokine receptor signaling. In C57BL/6 mice, the prostates injected with T. vaginalis mixed PCa cells were larger than those injected with PCa cells alone after 4 weeks. Expression of epithelial-mesenchymal transition markers and cyclin D1 in the prostate tissue injected with T. vaginalis mixed PCa cells increased than those of PCa cells alone. Collectively, it was suggested that inflammatory reactions by T. vaginalis-stimulated PCa cells increase the proliferation and invasion of PCa cells through cytokine-cytokine receptor signaling pathways. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | KOREAN SOC PARASITOLOGY | - |
dc.title | Proliferation of Mouse Prostate Cancer Cells Inflamed by Trichomonas vaginalis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | 김규식 | - |
dc.contributor.affiliatedAuthor | 김용석 | - |
dc.contributor.affiliatedAuthor | 류재숙 | - |
dc.identifier.doi | 10.3347/kjp.2021.59.6.547 | - |
dc.identifier.scopusid | 2-s2.0-85123036495 | - |
dc.identifier.wosid | 000739653300001 | - |
dc.identifier.bibliographicCitation | KOREAN JOURNAL OF PARASITOLOGY, v.59, no.6, pp.547 - 556 | - |
dc.relation.isPartOf | KOREAN JOURNAL OF PARASITOLOGY | - |
dc.citation.title | KOREAN JOURNAL OF PARASITOLOGY | - |
dc.citation.volume | 59 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 547 | - |
dc.citation.endPage | 556 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002786622 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Parasitology | - |
dc.relation.journalWebOfScienceCategory | Parasitology | - |
dc.subject.keywordPlus | MESENCHYMAL TRANSITION | - |
dc.subject.keywordPlus | CHRONIC INFLAMMATION | - |
dc.subject.keywordPlus | SUBSEQUENT RISK | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | GROWTH | - |
dc.subject.keywordPlus | PATHWAYS | - |
dc.subject.keywordPlus | CXCL1 | - |
dc.subject.keywordPlus | INVASIVENESS | - |
dc.subject.keywordPlus | PREVENTION | - |
dc.subject.keywordPlus | INFECTION | - |
dc.subject.keywordAuthor | Trichomonas vaginalis | - |
dc.subject.keywordAuthor | inflammation | - |
dc.subject.keywordAuthor | cancer | - |
dc.subject.keywordAuthor | cytokine | - |
dc.subject.keywordAuthor | chemokine | - |
dc.subject.keywordAuthor | receptor | - |
dc.identifier.url | https://parasitol.kr/journal/view.php?doi=10.3347/kjp.2021.59.6.547 | - |
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