Changes in treatment intent and target definition for preoperative radiotherapy after 18F-Fluorodeoxyglucose positron emission tomography in rectal cancer: A Meta-analysis
DC Field | Value | Language |
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dc.contributor.author | Lee, Soo Jin | - |
dc.contributor.author | Ha, Seunggyun | - |
dc.contributor.author | Pahk, Kisoo | - |
dc.contributor.author | Choi, Yun Young | - |
dc.contributor.author | Choi, Joon Young | - |
dc.contributor.author | Kim, Sungeun | - |
dc.contributor.author | Kwon, Hyun Woo | - |
dc.date.accessioned | 2022-07-06T11:05:14Z | - |
dc.date.available | 2022-07-06T11:05:14Z | - |
dc.date.created | 2022-01-05 | - |
dc.date.issued | 2021-12 | - |
dc.identifier.issn | 0720-048X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/140164 | - |
dc.description.abstract | Purpose: To evaluate the impact of 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) on changes in treatment plan and target definition for preoperative radiotherapy in patients with rectal cancer. Methods: Embase, PubMed, and Cochrane Library were searched up to November 2020 for all studies investigating the role of preoperative FDG PET in patients who underwent neoadjuvant radiotherapy before curative-intent surgery. The proportion of patients whose treatment plan (curative vs. palliative intent) or target definition was changed after FDG PET was analyzed. A random-effects model was used for pooled analysis. The change in target definition was compared between conventional radiological imaging-based target volume [gross tumor volume (GTV) or planning target volume (PTV)] and PET-based target volume (GTV or PTV) using the standardized mean difference (SMD) and 95% confidence interval (CI). Results: A total of 336 patients from twelve studies were included. In eight studies, PET changed either the treatment intent or target definition in 24.8% of patients (95% CI 15.1% to 37.9%, I2 = 69%). In ten studies, the PET-based GTV was lower than the conventional imaging-based target volume (SMD −7.0, 95% CI −1.39 to −0.01). However, there was no significant difference between conventional imaging-based and PET-based PTV (SMD −0.07, 95% CI −0.75 to 0.62). In six studies evaluating the initial staging based on PET, the initial staging (nodal or metastasis status) was changed in 53 of 229 patients (23.1%). Newly detected or additional distant metastases were identified in 22 patients (9.6%) after FDG PET. Conclusion: The use of FDG PET influences radiotherapy planning in a fourth of patients with rectal cancer. FDG PET can provide additive information for accurate tumor delineation, although PET-based PTV did not significantly change. These findings suggest that FDG PET may be beneficial to patients with rectal cancer before establishing a radiotherapy plan. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | Elsevier Ireland Ltd | - |
dc.title | Changes in treatment intent and target definition for preoperative radiotherapy after 18F-Fluorodeoxyglucose positron emission tomography in rectal cancer: A Meta-analysis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Choi, Yun Young | - |
dc.identifier.doi | 10.1016/j.ejrad.2021.110061 | - |
dc.identifier.scopusid | 2-s2.0-85119936740 | - |
dc.identifier.wosid | 000744234900008 | - |
dc.identifier.bibliographicCitation | European Journal of Radiology, v.145, pp.1 - 9 | - |
dc.relation.isPartOf | European Journal of Radiology | - |
dc.citation.title | European Journal of Radiology | - |
dc.citation.volume | 145 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 9 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.relation.journalWebOfScienceCategory | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.subject.keywordPlus | TOTAL MESORECTAL EXCISION | - |
dc.subject.keywordPlus | VOLUME DELINEATION | - |
dc.subject.keywordPlus | FDG-PET/CT | - |
dc.subject.keywordPlus | COMPUTED-TOMOGRAPHY | - |
dc.subject.keywordPlus | COLORECTAL-CANCER | - |
dc.subject.keywordPlus | CONFORMAL RADIOTHERAPY | - |
dc.subject.keywordPlus | IMPACT | - |
dc.subject.keywordPlus | MANAGEMENT | - |
dc.subject.keywordPlus | MRI | - |
dc.subject.keywordPlus | CT | - |
dc.subject.keywordAuthor | Fluorodeoxyglucose | - |
dc.subject.keywordAuthor | Positron emission tomography | - |
dc.subject.keywordAuthor | Radiotherapy planning | - |
dc.subject.keywordAuthor | Rectal cancer | - |
dc.subject.keywordAuthor | Treatment plan | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0720048X21005428?via%3Dihub | - |
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