Diabetes Status and Association with Risk of Tuberculosis among Korean Adults
DC Field | Value | Language |
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dc.contributor.author | Yoo, Jung Eun | - |
dc.contributor.author | Kim, Dahye | - |
dc.contributor.author | Han, Kyungdo | - |
dc.contributor.author | Rhee, Sang Youl | - |
dc.contributor.author | Shin, Dong Wook | - |
dc.contributor.author | Lee, Hyun | - |
dc.date.accessioned | 2022-07-06T13:21:07Z | - |
dc.date.available | 2022-07-06T13:21:07Z | - |
dc.date.created | 2021-11-22 | - |
dc.date.issued | 2021-09 | - |
dc.identifier.issn | 2574-3805 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/141013 | - |
dc.description.abstract | Importance: The risk of tuberculosis (TB) associated with diabetes status, considering impaired fasting glucose or duration of diabetes, has not been well established. Objective: To evaluate the association of diabetes status with the development of TB in the general population. Design, Setting, and Participants: This population-based cohort study used data from the Korean National Health Insurance System database. Adult participants without a history of TB who underwent a health screening in 2009 were included. Eligible participants were followed up for incident TB cases from 1 year after the day of health screening until December 31, 2018. Data analysis was performed from September 2019 to September 2020. Exposures: Five levels of diabetes status were evaluated: normal glucose, impaired fasting glucose (considered as without diabetes), new-onset diabetes, diabetes duration less than 5 years, and diabetes duration 5 years or longer (considered as having diabetes). Main Outcomes and Measures: Newly diagnosed TB. Results: Among 4423177 participants, the mean (SD) age was 46.5 (13.9) years, and there were 2597142 men (58.7%). A total of 26458 participants (0.6%) received a diagnosis of TB within a median (interquartile range) of 8.3 (8.1-8.6) years of follow-up. An increased risk of TB was observed in participants with diabetes compared with those without diabetes (adjusted hazard ratio [aHR], 1.48; 95% CI, 1.42-1.53). Although participants with impaired fasting glucose did not show an increased risk of TB incidence (aHR, 0.97; 95% CI, 0.93-1.01), the risk of TB incidence increased with diabetes duration (new-onset diabetes, aHR, 1.32; 95% CI, 1.23-1.42; diabetes duration <5 years, aHR, 1.45; 95% CI, 1.36-1.54; diabetes duration ≥5 years, aHR, 1.57; 95% CI, 1.48-1.66). Among participants with new-onset diabetes, compared with those in the lowest decile (fasting plasma glucose [FPG] level ≥126 but <128 mg/dL), the risk of TB was significantly increased for those in the highest decile (FPG level ≥202 mg/dL, aHR, 1.79; 95% CI, 1.42-2.26). Conclusions and Relevance: These findings suggest that longer diabetes duration is associated with development of TB, showing a dose-response association. Among participants with new-onset diabetes, incident TB was more common among those with FPG levels greater than or equal to 202 mg/dL. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | American Medical Association | - |
dc.title | Diabetes Status and Association with Risk of Tuberculosis among Korean Adults | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Hyun | - |
dc.identifier.doi | 10.1001/jamanetworkopen.2021.26099 | - |
dc.identifier.scopusid | 2-s2.0-85115250523 | - |
dc.identifier.wosid | 000698769100006 | - |
dc.identifier.bibliographicCitation | JAMA Network Open, v.4, no.9, pp.1 - 11 | - |
dc.relation.isPartOf | JAMA Network Open | - |
dc.citation.title | JAMA Network Open | - |
dc.citation.volume | 4 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 11 | - |
dc.type.rims | ART | - |
dc.type.docType | Article in Press | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.subject.keywordPlus | GLYCEMIC CONTROL | - |
dc.subject.keywordPlus | INSULIN-RESISTANCE | - |
dc.subject.keywordPlus | MELLITUS | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | MEN | - |
dc.identifier.url | https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2784396 | - |
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