Acetylated diacylglycerol 1‐palmitoyl‐2‐linoleoyl‐3‐acetyl‐rac‐glycerol in autoimmune arthritis and interstitial lung disease in skg mice
DC Field | Value | Language |
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dc.contributor.author | Lim, Doo-Ho | - |
dc.contributor.author | Lee, Eun-Ju | - |
dc.contributor.author | Lee, Hee-Seop | - |
dc.contributor.author | Kim, Do Hoon | - |
dc.contributor.author | Lee, Jae-Hyun | - |
dc.contributor.author | Jeong, Mi Ryeong | - |
dc.contributor.author | Hong, Seokchan | - |
dc.contributor.author | Lee, Chang-Keun | - |
dc.contributor.author | Yoo, Bin | - |
dc.contributor.author | Youn, Jeehee | - |
dc.contributor.author | Kim, Yong-Gil | - |
dc.date.accessioned | 2022-07-06T13:21:24Z | - |
dc.date.available | 2022-07-06T13:21:24Z | - |
dc.date.created | 2021-11-22 | - |
dc.date.issued | 2021-09 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/141018 | - |
dc.description.abstract | Acetylated diacylglycerol 1‐palmitoyl‐2‐linoleoyl‐3‐acetyl‐rac‐glycerol (PLAG) is a lipid molecule from the antlers of sika deer that might reduce inflammation by effectively controlling neutrophil infiltration, endothelial permeability and inflammatory chemokine production. There-fore, we evaluated the modulatory effect of PLAG on arthritis and interstitial lung disease (ILD) in an autoimmune arthritis model. We injected curdlan into SKG mice and PLAG was orally admin-istered every day from 3 weeks to 20 weeks after the curdlan injection. The arthritis score was measured every week after the curdlan injection. At 20 weeks post‐injection, the lung specimens were evaluated with H&E, Masson’s trichrome and multiplexed immunofluorescent staining. Serum cytokines were also analyzed using a Luminex multiple cytokine assay. PLAG administration decreased the arthritis score until 8 weeks after the curdlan injection. However, the effect was not sustained thereafter. A lung histology revealed severe inflammation and fibrosis in the cur-dlan‐induced SKG mice, which was attenuated in the PLAG‐treated mice. Furthermore, immuno-fluorescent staining of the lung tissue showed a GM‐CSF+ neutrophil accumulation and a decreased citrullinated histone 3 expression after PLAG treatment. PLAG also downregulated the levels of IL‐6 and TNF‐α and upregulated the level of sIL‐7Rα, an anti‐fibrotic molecule. Our results indicate that PLAG might have a preventative effect on ILD development through the resolution of NETosis in the lung. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.title | Acetylated diacylglycerol 1‐palmitoyl‐2‐linoleoyl‐3‐acetyl‐rac‐glycerol in autoimmune arthritis and interstitial lung disease in skg mice | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Youn, Jeehee | - |
dc.identifier.doi | 10.3390/biomedicines9091095 | - |
dc.identifier.scopusid | 2-s2.0-85114221857 | - |
dc.identifier.wosid | 000699076100001 | - |
dc.identifier.bibliographicCitation | Biomedicines, v.9, no.9, pp.1 - 10 | - |
dc.relation.isPartOf | Biomedicines | - |
dc.citation.title | Biomedicines | - |
dc.citation.volume | 9 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 10 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | NEUTROPHIL EXTRACELLULAR TRAPSRHEUMATOID-ARTHRITISBRONCHOALVEOLAR LAVAGEPULMONARY-FIBROSISGM-CSFINFLAMMATIONPNEUMONITISINJURYMONOACETYLDIGLYCERIDESCELLS | - |
dc.subject.keywordAuthor | interstitial lung disease | - |
dc.subject.keywordAuthor | PLAG | - |
dc.subject.keywordAuthor | NETosis | - |
dc.subject.keywordAuthor | arthritis | - |
dc.subject.keywordAuthor | autoimmune | - |
dc.identifier.url | https://www.mdpi.com/2227-9059/9/9/1095 | - |
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