Nanocomplex-Mediated In Vivo Programming to Chimeric Antigen Receptor-M1 Macrophages for Cancer Therapy
DC Field | Value | Language |
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dc.contributor.author | Kang, Mikyung | - |
dc.contributor.author | Lee, Seong Ho | - |
dc.contributor.author | Kwon, Miji | - |
dc.contributor.author | Byun, Junho | - |
dc.contributor.author | Kim, Dongyoon | - |
dc.contributor.author | Kim, Cheesue | - |
dc.contributor.author | Koo, Sagang | - |
dc.contributor.author | Kwon, Sung Pil | - |
dc.contributor.author | Moon, Sangjun | - |
dc.contributor.author | Jung, Mungyo | - |
dc.contributor.author | Hong, Jihye | - |
dc.contributor.author | Go, Seokhyeong | - |
dc.contributor.author | Song, Seuk Young | - |
dc.contributor.author | Choi, Jae Hyun | - |
dc.contributor.author | Hyeon, Taeghwan | - |
dc.contributor.author | Oh, Yu-Kyoung | - |
dc.contributor.author | Park, Hee Ho | - |
dc.contributor.author | Kim, Byung-Soo | - |
dc.date.accessioned | 2022-07-06T14:34:22Z | - |
dc.date.available | 2022-07-06T14:34:22Z | - |
dc.date.created | 2021-11-22 | - |
dc.date.issued | 2021-09 | - |
dc.identifier.issn | 0935-9648 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/141106 | - |
dc.description.abstract | Chimeric antigen receptor-T (CAR-T) cell immunotherapy has shown impressive clinical outcomes for hematologic malignancies. However, its broader applications are challenged due to its complex ex vivo cell-manufacturing procedures and low therapeutic efficacy against solid tumors. The limited therapeutic effects are partially due to limited CAR-T cell infiltration to solid tumors and inactivation of CAR-T cells by the immunosuppressive tumor microenvironment. Here, a facile approach is presented to in vivo program macrophages, which can intrinsically penetrate solid tumors, into CAR-M1 macrophages displaying enhanced cancer-directed phagocytosis and anti-tumor activity. In vivo injected nanocomplexes of macrophage-targeting nanocarriers and CAR-interferon-gamma-encoding plasmid DNA induce CAR-M1 macrophages that are capable of CAR-mediated cancer phagocytosis, anti-tumor immunomodulation, and inhibition of solid tumor growth. Together, this study describes an off-the-shelf CAR-macrophage therapy that is effective for solid tumors and avoids the complex and costly processes of ex vivo CAR-cell manufacturing. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | WILEY-V C H VERLAG GMBH | - |
dc.title | Nanocomplex-Mediated In Vivo Programming to Chimeric Antigen Receptor-M1 Macrophages for Cancer Therapy | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, Hee Ho | - |
dc.identifier.doi | 10.1002/adma.202103258 | - |
dc.identifier.scopusid | 2-s2.0-85114694000 | - |
dc.identifier.wosid | 000695038700001 | - |
dc.identifier.bibliographicCitation | ADVANCED MATERIALS, v.33, no.43, pp.1 - 16 | - |
dc.relation.isPartOf | ADVANCED MATERIALS | - |
dc.citation.title | ADVANCED MATERIALS | - |
dc.citation.volume | 33 | - |
dc.citation.number | 43 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 16 | - |
dc.type.rims | ART | - |
dc.type.docType | Article; Early Access | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalResearchArea | Physics | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Physical | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Physics, Applied | - |
dc.relation.journalWebOfScienceCategory | Physics, Condensed Matter | - |
dc.subject.keywordPlus | PIGGYBAC TRANSPOSON SYSTEM | - |
dc.subject.keywordPlus | TARGETED DNA DELIVERY | - |
dc.subject.keywordPlus | CAR-T-CELLS | - |
dc.subject.keywordPlus | ANTITUMOR IMMUNITY | - |
dc.subject.keywordPlus | INTERFERON-GAMMA | - |
dc.subject.keywordPlus | DENDRITIC CELLS | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | ALK | - |
dc.subject.keywordPlus | POLYETHYLENIMINE | - |
dc.subject.keywordAuthor | cancer therapy | - |
dc.subject.keywordAuthor | CAR-macrophage | - |
dc.subject.keywordAuthor | cytotoxic T lymphocyte | - |
dc.subject.keywordAuthor | DNA | - |
dc.subject.keywordAuthor | polymer nanocomplex | - |
dc.subject.keywordAuthor | in situ transfection | - |
dc.identifier.url | https://onlinelibrary.wiley.com/doi/10.1002/adma.202103258 | - |
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