장내 미생물과 염증장질환open accessIntestinal microbiota and inflammatory bowel diseases
- Other Titles
- Intestinal microbiota and inflammatory bowel diseases
- Authors
- 은창수
- Issue Date
- Sep-2021
- Publisher
- KOREAN MEDICAL ASSOC
- Keywords
- Gastrointestinal microbiome; Inflammatory bowel diseases; Host microbial interactions
- Citation
- JOURNAL OF THE KOREAN MEDICAL ASSOCIATION, v.64, no.9, pp.588 - 595
- Indexed
- SCOPUS
KCI
- Journal Title
- JOURNAL OF THE KOREAN MEDICAL ASSOCIATION
- Volume
- 64
- Number
- 9
- Start Page
- 588
- End Page
- 595
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/141145
- DOI
- 10.5124/jkma.2021.64.9.588
- ISSN
- 1975-8456
- Abstract
- Background: The prevalence of inflammatory bowel diseases (IBD) has been rapidly increasing over the past several decades in Korea. IBD appears to be resulted from inappropriate and chronic activation of the mucosal immune system driven by stimuli such as intestinal microbiota and various environmental factors in genetically susceptible individuals. Current Concepts: Recent advances in next-generation sequencing technology have identified alterations in the composition and function of the intestinal microbiota in individuals with IBD. Dysbiosis in patients with IBD is characterized by decreased bacterial diversity combined with an expansion of putative aggressive species and a reduction in protective species. Altered microbial composition and function in IBD correlates with increased immune stimulation, epithelial dysfunction, or enhanced mucosal permeability. Thus, dysbiosis may play an essential role in the pathogenesis of IBD. Discussion and Conclusion: Although it is currently unclear whether dysbiosis is a cause or consequence of intestinal inflammation in IBD, several microbial-based and microbial-targeted therapies have yielded promising early results.
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