USP48 Governs Cell Cycle Progression by Regulating the Protein Level of Aurora B
DC Field | Value | Language |
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dc.contributor.author | Antao, Ainsley Mike | - |
dc.contributor.author | Kaushal, Kamini | - |
dc.contributor.author | Das, Soumyadip | - |
dc.contributor.author | Singh, Vijai | - |
dc.contributor.author | Suresh, Bharathi | - |
dc.contributor.author | Kim, Kye-Seong | - |
dc.contributor.author | Ramakrishna, Suresh | - |
dc.date.accessioned | 2022-07-06T16:01:21Z | - |
dc.date.available | 2022-07-06T16:01:21Z | - |
dc.date.created | 2021-11-22 | - |
dc.date.issued | 2021-08 | - |
dc.identifier.issn | 1661-6596 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/141379 | - |
dc.description.abstract | Deubiquitinating enzymes play key roles in the precise modulation of Aurora B-an essential cell cycle regulator. The expression of Aurora B increases before the onset of mitosis and decreases during mitotic exit; an imbalance in these levels has a severe impact on the fate of the cell cycle. Dysregulation of Aurora B can lead to aberrant chromosomal segregation and accumulation of errors during mitosis, eventually resulting in cytokinesis failure. Thus, it is essential to identify the precise regulatory mechanisms that modulate Aurora B levels during the cell division cycle. Using a deubiquitinase knockout strategy, we identified USP48 as an important candidate that can regulate Aurora B protein levels during the normal cell cycle. Here, we report that USP48 interacts with and stabilizes the Aurora B protein. Furthermore, we showed that the deubiquitinating activity of USP48 helps to maintain the steady-state levels of Aurora B protein by regulating its half-life. Finally, USP48 knockout resulted in delayed progression of cell cycle due to accumulation of mitotic defects and ultimately cytokinesis failure, suggesting the role of USP48 in cell cycle regulation. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.title | USP48 Governs Cell Cycle Progression by Regulating the Protein Level of Aurora B | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Kye-Seong | - |
dc.contributor.affiliatedAuthor | Ramakrishna, Suresh | - |
dc.identifier.doi | 10.3390/ijms22168508 | - |
dc.identifier.scopusid | 2-s2.0-85112590164 | - |
dc.identifier.wosid | 000689288300001 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.22, no.16, pp.1 - 17 | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.citation.title | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.citation.volume | 22 | - |
dc.citation.number | 16 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 17 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.subject.keywordPlus | CHROMOSOMAL PASSENGER COMPLEX | - |
dc.subject.keywordPlus | MITOTIC PROGRESSION | - |
dc.subject.keywordPlus | KINASE INHIBITORS | - |
dc.subject.keywordPlus | DNA-REPLICATION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | OVEREXPRESSION | - |
dc.subject.keywordPlus | PHOSPHORYLATION | - |
dc.subject.keywordPlus | UBIQUITINATION | - |
dc.subject.keywordPlus | DISRUPTION | - |
dc.subject.keywordPlus | CARCINOMA | - |
dc.subject.keywordAuthor | aurora kinase | - |
dc.subject.keywordAuthor | CRISPR | - |
dc.subject.keywordAuthor | Cas9 | - |
dc.subject.keywordAuthor | DUBs | - |
dc.subject.keywordAuthor | gene knockout | - |
dc.subject.keywordAuthor | mitotic regulator | - |
dc.subject.keywordAuthor | post-translational modifications | - |
dc.identifier.url | https://www.mdpi.com/1422-0067/22/16/8508 | - |
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