Mast cell tryptase-PAR2 pathway in proliferation of prostatic stromal cells reacted with Trichomonas vaginalis
DC Field | Value | Language |
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dc.contributor.author | Noh, Chang-Suk | - |
dc.contributor.author | Chung, Hyo-Yeoung | - |
dc.contributor.author | Han, Ik-Hwan | - |
dc.contributor.author | Kim, Jung-Hyun | - |
dc.contributor.author | Kim, Yu-Mi | - |
dc.contributor.author | Ryu, Jae-Sook | - |
dc.date.accessioned | 2022-07-06T16:05:13Z | - |
dc.date.available | 2022-07-06T16:05:13Z | - |
dc.date.created | 2021-07-14 | - |
dc.date.issued | 2021-08 | - |
dc.identifier.issn | 0141-9838 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/141447 | - |
dc.description.abstract | We investigated whether tryptase released from mast cells activated by prostate stromal cells (PSC) reacted with Trichomonas vaginalis (Tv) promoted the proliferation of PSC through protease- activated receptor 2 (PAR2). Conditioned medium of PSC was prepared by stimulating them with Tv (Trichomonad-conditioned medium (TCM)), and mast cell-conditioned medium were prepared by incubating them with TCM (mast cell-TCM (M-TCM)). Mast cells incubated with TCM migrated more efficiently and produced more beta-hexosaminidase and tryptase. M-TCM containing tryptase increased the proliferation of PSC, while inhibition of tryptase decreased proliferation. Expression of signalling molecules such as PAR2, p-ERK, COX-2, 15d-PGJ(2) and PPAR gamma, known to be involved in the tryptase-PAR2 pathway, increased in response to M-TCM, and blocking any of these signals decreased proliferation, indicating that tryptase-PAR2 signalling is involved in the proliferation of PSC. Inhibition of tryptase and PAR2 led to reduced expression of PAR2, p-ERK, COX-2, 15d-PGJ(2) and PPAR gamma, while inhibition of ERK or COX-2 reduced the expression of COX-2, 15d-PGJ(2) and PPAR gamma indicating that the tryptase-PAR2 pathway proceeds in the order p-ERK, COX-2, 15d-PGJ(2), and PPAR gamma. These results show that interaction between PSC stimulated with Tv and mast cells causes proliferation of PSC through the tryptase-PAR2 pathway. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.title | Mast cell tryptase-PAR2 pathway in proliferation of prostatic stromal cells reacted with Trichomonas vaginalis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Yu-Mi | - |
dc.contributor.affiliatedAuthor | Ryu, Jae-Sook | - |
dc.identifier.doi | 10.1111/pim.12868 | - |
dc.identifier.scopusid | 2-s2.0-85107352374 | - |
dc.identifier.wosid | 000656804500001 | - |
dc.identifier.bibliographicCitation | PARASITE IMMUNOLOGY, v.43, no.8, pp.1 - 9 | - |
dc.relation.isPartOf | PARASITE IMMUNOLOGY | - |
dc.citation.title | PARASITE IMMUNOLOGY | - |
dc.citation.volume | 43 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 9 | - |
dc.type.rims | ART | - |
dc.type.docType | Article; Early Access | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalResearchArea | Parasitology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.relation.journalWebOfScienceCategory | Parasitology | - |
dc.subject.keywordPlus | PROTEASE-ACTIVATED RECEPTOR-2 | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | FIBROBLASTS | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | PROGRESSION | - |
dc.subject.keywordPlus | CROSSTALK | - |
dc.subject.keywordPlus | GAMMA | - |
dc.subject.keywordPlus | COX2 | - |
dc.subject.keywordPlus | PAR2 | - |
dc.subject.keywordPlus | J(2) | - |
dc.subject.keywordAuthor | inflammation | - |
dc.subject.keywordAuthor | mast cell | - |
dc.subject.keywordAuthor | protease | - |
dc.subject.keywordAuthor | Trichomonas vaginalis | - |
dc.identifier.url | https://onlinelibrary.wiley.com/doi/10.1111/pim.12868 | - |
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