Duodenal-jejunal bypass maintains hepatic S-adenosylmethionine/S-homocysteine ratio in diet-induced obese rats
DC Field | Value | Language |
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dc.contributor.author | Kim, Mikyung | - |
dc.contributor.author | Rho, Yunmee | - |
dc.contributor.author | Park, Rhoeun | - |
dc.contributor.author | Jung, Jeeyoun | - |
dc.contributor.author | Hwang, Geum-Sook | - |
dc.contributor.author | Seo, Youn Kyoung | - |
dc.contributor.author | Seo, Ji Hae | - |
dc.contributor.author | Heo, Yoonseok | - |
dc.contributor.author | Ha, Tae Kyung | - |
dc.contributor.author | Ha, Eunyoung | - |
dc.date.accessioned | 2022-07-06T16:29:05Z | - |
dc.date.available | 2022-07-06T16:29:05Z | - |
dc.date.created | 2021-05-14 | - |
dc.date.issued | 2021-07 | - |
dc.identifier.issn | 1550-7289 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/141577 | - |
dc.description.abstract | We previously reported that the duodenal-jejunal bypass (DJB) surgery altered trans-sulfuration and purine metabolism via flux changes in one-carbon metabolism in the liver. In this study, we extended our study to gain further insight into mechanistic details of how the DJB-induced flux changes in one-carbon metabolism contributes to the improvement of diet-induced nonalcoholic fatty liver disease (NAFLD). Rodents were subjected to surgical (sham operation and DJB) or dietary (reduced food supply to follow the weight changes in the DJB-group) interventions. The microscopic features of the liver were examined by immunohistochemistry. The expressions of genes in lipid synthesis and in one-carbon cycle in the liver were analyzed by real-time PCR and western blotting. Metabolic changes in the liver were determined. We observed that DJB reduces hepatic steatosis and improves insulin sensitivity in both high-fat diet (HFD)-fed rats and mice. Metabolic analyses revealed that the possible underlying mechanism may involve decreased SAM/SAH ratio via down-regulation of SAM synthesizing enzyme and up-regulation of SAM catabolizing enzyme. We also found in mice that DJB-mediated attenuation of hepatic steatosis is independent of weight loss. DJB also increased hepatic expression levels of GNMT while decreased those of PEMT and BHMT, a change in one-carbon metabolism that may decrease the ratio of SAM to SAH, thereby resulting in the prevention of fat accumulation in the liver. Thus, we suggest that the change in one-carbon metabolism, especially the SAM metabolism, may contribute to the improvement of diet-induced fatty liver disease after DJB surgery. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | Elsevier BV | - |
dc.title | Duodenal-jejunal bypass maintains hepatic S-adenosylmethionine/S-homocysteine ratio in diet-induced obese rats | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Ha, Tae Kyung | - |
dc.identifier.doi | 10.1016/j.soard.2021.02.011 | - |
dc.identifier.scopusid | 2-s2.0-85102989248 | - |
dc.identifier.wosid | 000662213600018 | - |
dc.identifier.bibliographicCitation | Surgery for Obesity and Related Diseases, v.17, no.7, pp.1359 - 1368 | - |
dc.relation.isPartOf | Surgery for Obesity and Related Diseases | - |
dc.citation.title | Surgery for Obesity and Related Diseases | - |
dc.citation.volume | 17 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 1359 | - |
dc.citation.endPage | 1368 | - |
dc.type.rims | ART | - |
dc.type.docType | 정기학술지(Article(Perspective Article포함)) | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Surgery | - |
dc.relation.journalWebOfScienceCategory | Surgery | - |
dc.subject.keywordPlus | FATTY LIVER-DISEASE | - |
dc.subject.keywordPlus | METHIONINE METABOLISM | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordPlus | EPIDEMIOLOGY | - |
dc.subject.keywordPlus | METHYLATION | - |
dc.subject.keywordPlus | STEATOSIS | - |
dc.subject.keywordPlus | INJURY | - |
dc.subject.keywordAuthor | 1-Carbon metabolism | - |
dc.subject.keywordAuthor | Metabolic surgery | - |
dc.subject.keywordAuthor | NAFLD | - |
dc.subject.keywordAuthor | Obesity | - |
dc.subject.keywordAuthor | S-adenosylhomocysteine | - |
dc.subject.keywordAuthor | S-adenosylmethionine | - |
dc.identifier.url | https://www.clinicalkey.com/#!/content/playContent/1-s2.0-S1550728921000939?returnurl=https:%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1550728921000939%3Fshowall%3Dtrue&referrer= | - |
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