Prognosis of patients with axillary lymph node metastases from occult breast cancer: analysis of multicenter data
DC Field | Value | Language |
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dc.contributor.author | Kim, Haeyoung | - |
dc.contributor.author | Park, Won | - |
dc.contributor.author | Kim, Su Ssan | - |
dc.contributor.author | Ahn, Sung Ja | - |
dc.contributor.author | Kim, Yong Bae | - |
dc.contributor.author | Kim, Tae Hyun | - |
dc.contributor.author | Kim, Jin Hee | - |
dc.contributor.author | Choi, Jin-Hwa | - |
dc.contributor.author | Park, Hae Jin | - |
dc.contributor.author | Chang, Jee Suk | - |
dc.contributor.author | Choi, Doo Ho | - |
dc.date.accessioned | 2022-07-06T17:17:09Z | - |
dc.date.available | 2022-07-06T17:17:09Z | - |
dc.date.created | 2021-08-25 | - |
dc.date.issued | 2021-06 | - |
dc.identifier.issn | 2234-1900 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/141725 | - |
dc.description.abstract | Purpose: This study was conducted to evaluate prognosis of patients with level I/II axillary lymph node metastases from occult breast cancer (OBC). Materials and Methods: Data of 53 patients with OBC who received axillary lymph node dissection (ALND) positive/negative (+/–) breast-conserving surgery between 2001 and 2013 were retrospectively collected at seven hospitals in Korea. The median number of positive lymph nodes (+LNs) was 2. Seventeen patients (32.1%) had >3 +LNs. A total of 48 patients (90.6%) received radiotherapy. Extents of radiotherapy were as follows: whole-breast (WB; n = 11), regional lymph node (RLN; n = 2), and WB plus RLN (n = 35). Results: The median follow-up time was 85 months. Recurrence was found in four patients: two in the breast, one in RLN, and one in the breast and RLN. The 5-year and 7-year disease-free survival (DFS) rates were 96.1% and 93.5%, respectively. Molecular subtype and receipt of breast radiotherapy were significantly associated with DFS. Patients with estrogen receptor negative, progesterone receptor negative, and human epidermal growth factor receptor 2 negative (ER-/PR-/HER2-) subtype had significantly lower 7-year DFS than those with non-ER-/PR-/HER2- tumor (76.9% vs. 100.0%; p = 0.03). Whole breast irradiation (WBI) was significantly associated with a higher 7-year DFS rate (94.7% for WBI group vs. 83.3% for non-WBI group; p = 0.01). Other factors including patient’s age, number of +LNs, taxane chemotherapy, and RLN irradiation were not associated with DFS. Conclusion: Patients with OBC achieved favorable outcome after ALND and breast-targeting treatment. Molecular subtype and receipt of WBI was significant factors for DFS. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | 대한방사선종양학회 | - |
dc.title | Prognosis of patients with axillary lymph node metastases from occult breast cancer: analysis of multicenter data | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, Hae Jin | - |
dc.identifier.doi | 10.3857/roj.2021.00241 | - |
dc.identifier.scopusid | 2-s2.0-85110498677 | - |
dc.identifier.wosid | 000668605400004 | - |
dc.identifier.bibliographicCitation | Radiation oncology journal, v.39, no.2, pp.107 - 112 | - |
dc.relation.isPartOf | Radiation oncology journal | - |
dc.citation.title | Radiation oncology journal | - |
dc.citation.volume | 39 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 107 | - |
dc.citation.endPage | 112 | - |
dc.type.rims | ART | - |
dc.identifier.kciid | ART002732657 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.description.journalRegisteredClass | other | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.subject.keywordPlus | MANAGEMENT | - |
dc.subject.keywordPlus | OUTCOMES | - |
dc.subject.keywordAuthor | Unknown primary neoplasms | - |
dc.subject.keywordAuthor | Breast neoplasm | - |
dc.subject.keywordAuthor | Lymph nodes | - |
dc.subject.keywordAuthor | Radiotherapy | - |
dc.identifier.url | https://www.e-roj.org/journal/view.php?doi=10.3857/roj.2021.00241 | - |
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