Optimal control of effector-tumor-normal cells dynamics in presence of adoptive immunotherapy
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Das, Anusmita | - |
dc.contributor.author | Dehingia, Kaushik | - |
dc.contributor.author | Sharmah, Hemanta Kumar | - |
dc.contributor.author | Park, Choonkil | - |
dc.contributor.author | Lee, Jung Rye | - |
dc.contributor.author | Sadri, Khadijeh | - |
dc.contributor.author | Hosseini, Kamyar | - |
dc.contributor.author | Salahshour, Soheil | - |
dc.date.accessioned | 2022-07-06T17:18:56Z | - |
dc.date.available | 2022-07-06T17:18:56Z | - |
dc.date.created | 2021-07-15 | - |
dc.date.issued | 2021-06 | - |
dc.identifier.issn | 2473-6988 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/141760 | - |
dc.description.abstract | Interactive dynamics between effector-tumor-normal cells in a mathematical model related to the growth of cancer in presence of immunotherapy has been discussed in the present paper. Adoptive immunotherapy has been added to the original model proposed by De Pillis et al. [1]. This has been done to get rid of the tumor cells. Different dynamical behaviours of the modified systems have been studied. The existence of the solution and global stability conditions of the healthy equilibrium point is addressed. Corresponding optimal control problem has been formulated to find the best possible way of administration of adoptive immunotherapy by which cancer cells can be eradicated without putting the patient at any health-related risk. To achieve this purpose, the quadratic control principle has been adopted. The dynamical behaviour of the effector-tumor-normal cells model with control is also numerically verified and demonstrated. Through numerical simulations, it is formally shown that the optimal regimens eradicate the tumor load in less time without putting the patientso health at any risk. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | AMER INST MATHEMATICAL SCIENCES-AIMS | - |
dc.title | Optimal control of effector-tumor-normal cells dynamics in presence of adoptive immunotherapy | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, Choonkil | - |
dc.identifier.doi | 10.3934/math.2021570 | - |
dc.identifier.scopusid | 2-s2.0-85108823214 | - |
dc.identifier.wosid | 000683418700018 | - |
dc.identifier.bibliographicCitation | AIMS MATHEMATICS, v.6, no.9, pp.9813 - 9834 | - |
dc.relation.isPartOf | AIMS MATHEMATICS | - |
dc.citation.title | AIMS MATHEMATICS | - |
dc.citation.volume | 6 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 9813 | - |
dc.citation.endPage | 9834 | - |
dc.type.rims | ART | - |
dc.type.docType | 정기학술지(Article(Perspective Article포함)) | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Mathematics | - |
dc.relation.journalWebOfScienceCategory | Mathematics, Applied | - |
dc.relation.journalWebOfScienceCategory | Mathematics | - |
dc.subject.keywordPlus | MATHEMATICAL-MODEL | - |
dc.subject.keywordPlus | SYSTEM | - |
dc.subject.keywordPlus | CHAOS | - |
dc.subject.keywordAuthor | mathematical model of cancer | - |
dc.subject.keywordAuthor | adoptive immunotherapy | - |
dc.subject.keywordAuthor | stability analysis | - |
dc.subject.keywordAuthor | optimal control problem | - |
dc.subject.keywordAuthor | quadratic control principle | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
222, Wangsimni-ro, Seongdong-gu, Seoul, 04763, Korea+82-2-2220-1365
COPYRIGHT © 2021 HANYANG UNIVERSITY.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.