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Rate of central corneal thickness changes in primary angle closure eyes: long-term follow-up results

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dc.contributor.authorPark, Hae Min-
dc.contributor.authorChoi, Jiin-
dc.contributor.authorLee, Won June-
dc.contributor.authorUhm, Ki Bang-
dc.date.accessioned2022-07-07T00:30:56Z-
dc.date.available2022-07-07T00:30:56Z-
dc.date.created2021-07-14-
dc.date.issued2021-03-
dc.identifier.issn1471-2415-
dc.identifier.urihttps://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/142190-
dc.description.abstractBackground Central corneal thickness (CCT) and its association with intraocular pressure, which is a pivotal parameter in glaucoma management, has previously been reported. In this study, we intended to investigate the long-term change of CCT in terms of rate in eyes with primary angle-closure (PAC). Additionally, we aimed to analyze events that could affect CCT. Methods In this retrospective study, 26 patients with PAC who had a follow-up period of more than 5 years were analyzed. The rate of CCT changes from baseline was evaluated from the serial CCT measurements over the average follow-up period. The pattern of CCT change rate according to modes of treatment and history of angle-closure attack was analyzed using the repeated linear mixed model analysis. Results A total of 52 eyes were enrolled. The CCT reduction rate of the entire study population was − 0.72 ± 0.22 μm/yr (P = 0.001) with statistical significance. The CCT thinning rate of the laser peripheral iridotomy (PI) group was − 0.53 ± 0.25 μm/yr (P = 0.034) and that of the surgical trabeculectomy group was − 1.32 ± 0.43 μm/yr (P = 0.002), and it was not statistically significant (P = 0.112). The rate of CCT thinning in patients with a history of acute angle-closure attack was − 0.81 ± 0.31 μm/yr (P = 0.009) and that in patients without an attack was − 0.63 ± 0.30 μm/yr (P = 0.001), and it was not statistically significant (P = 0.680). Baseline CCT appeared to be the only significant factor affecting the rate of CCT changes (P < 0.001). Conclusions We found a significant reduction in CCT over a long observation period in PAC eyes. We also found that the rates of CCT reduction were not affected by different treatment modalities or acute angle-closure attacks. The analysis of long-term CCT changes in conjunction with baseline CCT would also be helpful in the clinical evaluation of the PAC patients.-
dc.language영어-
dc.language.isoen-
dc.publisherBMC-
dc.titleRate of central corneal thickness changes in primary angle closure eyes: long-term follow-up results-
dc.typeArticle-
dc.contributor.affiliatedAuthorLee, Won June-
dc.identifier.doi10.1186/s12886-021-01908-4-
dc.identifier.scopusid2-s2.0-85103085860-
dc.identifier.wosid000632828500002-
dc.identifier.bibliographicCitationBMC OPHTHALMOLOGY, v.21, no.1, pp.1 - 10-
dc.relation.isPartOfBMC OPHTHALMOLOGY-
dc.citation.titleBMC OPHTHALMOLOGY-
dc.citation.volume21-
dc.citation.number1-
dc.citation.startPage1-
dc.citation.endPage10-
dc.type.rimsART-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.isOpenAccessY-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaOphthalmology-
dc.relation.journalWebOfScienceCategoryOphthalmology-
dc.subject.keywordPlusMANIFEST GLAUCOMA TRIAL-
dc.subject.keywordPlusNORMAL-TENSION GLAUCOMA-
dc.subject.keywordPlusINTRAOCULAR-PRESSURE-
dc.subject.keywordPlusOCULAR HYPERTENSION-
dc.subject.keywordPlusRISK-FACTOR-
dc.subject.keywordPlusHYSTERESIS-
dc.subject.keywordPlusPARAMETERS-
dc.subject.keywordPlusCHINESE-
dc.subject.keywordPlusLATANOPROST-
dc.subject.keywordPlusASSOCIATION-
dc.subject.keywordAuthorGlaucoma-
dc.subject.keywordAuthorCentral corneal thickness-
dc.subject.keywordAuthorCorneal biomechanics-
dc.subject.keywordAuthorPrimary angle-closure-
dc.subject.keywordAuthorGlaucoma management-
dc.identifier.urlhttps://bmcophthalmol.biomedcentral.com/articles/10.1186/s12886-021-01908-4-
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