Comparison of Longitudinal Changes of Cerebral Small Vessel Disease Markers and Cognitive Function Between Subcortical Vascular Mild Cognitive Impairment With and Without NOTCH3 Variant: A 5-Year Follow-Up Study
DC Field | Value | Language |
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dc.contributor.author | Yoon, Cindy W. | - |
dc.contributor.author | Kim, Young-Eun | - |
dc.contributor.author | Kim, Hee Jin | - |
dc.contributor.author | Ki, Chang-Seok | - |
dc.contributor.author | Lee, Hyejoo | - |
dc.contributor.author | Rha, Joung-Ho | - |
dc.contributor.author | Na, Duk L. | - |
dc.contributor.author | Seo, Sang Won | - |
dc.date.accessioned | 2022-07-07T00:54:32Z | - |
dc.date.available | 2022-07-07T00:54:32Z | - |
dc.date.created | 2021-07-14 | - |
dc.date.issued | 2021-02 | - |
dc.identifier.issn | 1664-2295 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/142296 | - |
dc.description.abstract | No study yet has compared the longitudinal course and prognosis between subcortical vascular cognitive impairment patients with and without genetic component. In this study, we compared the longitudinal changes in cerebral small vessel disease markers and cognitive function between subcortical vascular mild cognitive impairment (svMCI) patients with and without NOTCH3 variant [NOTCH3(+) svMCI vs. NOTCH3(-) svMCI]. We prospectively recruited patients with svMCI and screened for NOTCH3 variants by sequence analysis for mutational hotspots in the NOTCH3 gene. Patients were annually followed-up for 5 years through clinical interviews, neuropsychological tests, and brain magnetic resonance imaging. Among 63 svMCI patients, 9 (14.3%) had either known mutations or possible pathogenic variants. The linear mixed effect models showed that the NOTCH3(+) svMCI group had much greater increases in the lacune and cerebral microbleed counts than the NOTCH3(-) svMCI group. However, there were no significant differences between the two groups regarding dementia conversion rate and neuropsychological score changes over 5 years. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | FRONTIERS MEDIA SA | - |
dc.title | Comparison of Longitudinal Changes of Cerebral Small Vessel Disease Markers and Cognitive Function Between Subcortical Vascular Mild Cognitive Impairment With and Without NOTCH3 Variant: A 5-Year Follow-Up Study | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Young-Eun | - |
dc.identifier.doi | 10.3389/fneur.2021.586366 | - |
dc.identifier.scopusid | 2-s2.0-85102424095 | - |
dc.identifier.wosid | 000627316600001 | - |
dc.identifier.bibliographicCitation | FRONTIERS IN NEUROLOGY, v.12, pp.1 - 7 | - |
dc.relation.isPartOf | FRONTIERS IN NEUROLOGY | - |
dc.citation.title | FRONTIERS IN NEUROLOGY | - |
dc.citation.volume | 12 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 7 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Clinical Neurology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.subject.keywordPlus | genomic DNA | - |
dc.subject.keywordPlus | Notch3 receptor | - |
dc.subject.keywordPlus | Pittsburgh compound Baged | - |
dc.subject.keywordPlus | Article | - |
dc.subject.keywordPlus | brain hemorrhage | - |
dc.subject.keywordPlus | brain radiography | - |
dc.subject.keywordPlus | CADASIL | - |
dc.subject.keywordPlus | cognition | - |
dc.subject.keywordPlus | comparative study | - |
dc.subject.keywordPlus | controlled study | - |
dc.subject.keywordPlus | dementia | - |
dc.subject.keywordPlus | disease course | - |
dc.subject.keywordPlus | disease marker | - |
dc.subject.keywordPlus | female | - |
dc.subject.keywordPlus | fluid-attenuated inversion recovery imaging | - |
dc.subject.keywordPlus | follow up | - |
dc.subject.keywordPlus | gene mutation | - |
dc.subject.keywordPlus | genetic screening | - |
dc.subject.keywordPlus | genetic variation | - |
dc.subject.keywordPlus | human | - |
dc.subject.keywordPlus | image analysis | - |
dc.subject.keywordPlus | interview | - |
dc.subject.keywordPlus | lacunar stroke | - |
dc.subject.keywordPlus | linear mixed effect model | - |
dc.subject.keywordPlus | longitudinal study | - |
dc.subject.keywordPlus | major clinical study | - |
dc.subject.keywordPlus | male | - |
dc.subject.keywordPlus | mild cognitive impairment | - |
dc.subject.keywordPlus | molecular genetics | - |
dc.subject.keywordPlus | neuropsychological test | - |
dc.subject.keywordPlus | NOTCH3 gene | - |
dc.subject.keywordPlus | nuclear magnetic resonance imaging | - |
dc.subject.keywordPlus | positron emission tomography | - |
dc.subject.keywordPlus | prospective study | - |
dc.subject.keywordPlus | sequence analysis | - |
dc.subject.keywordPlus | South Korea | - |
dc.subject.keywordPlus | statistical model | - |
dc.subject.keywordPlus | subcortical vascular cognitive impairment | - |
dc.subject.keywordAuthor | NOTCH3 | - |
dc.subject.keywordAuthor | CADASIL | - |
dc.subject.keywordAuthor | lacune | - |
dc.subject.keywordAuthor | cerebral microbleed | - |
dc.subject.keywordAuthor | subcortical vascular cognitive impairment | - |
dc.identifier.url | https://www.frontiersin.org/articles/10.3389/fneur.2021.586366/full | - |
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